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Literature DB >> 23615712

MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway.

Nan Li¹, Anliu Tang, Shuo Huang, Zeng Li, Xiayu Li, Shourong Shen, Jian Ma, Xiaoyan Wang.

Abstract

Recent data strongly suggests the profound role of miRNAs in cancer progression. Here, we showed miR-126 expression was much lower in HCT116, SW620 and HT-29 colon cancer cells with highly metastatic potential and miR-126 downregulation was more frequent in colorectal cancers with metastasis. Restored miR-126 expression inhibited HT-29 cell growth, cell-cycle progression and invasion. Mechanically, microarray results combined with bioinformatic and experimental analysis demonstrated miR-126 exerted cancer suppressor role via inhibiting RhoA/ROCK signaling pathway. These results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies.

Entities: Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23615712 DOI： 10.1007/s11010-013-1664-0

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

46 in total

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Journal: Biochim Biophys Acta Date: 2004-12-17

Review 2. Role of Rho GTPases in breast cancer.

Authors: Yong Tang; Lola Olufemi; Man-Tzu Wang; Daotai Nie
Journal: Front Biosci Date: 2008-01-01

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Authors: Chang-Zheng Chen; Ling Li; Harvey F Lodish; David P Bartel
Journal: Science Date: 2003-12-04 Impact factor: 47.728

4. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

Authors: Nozomu Yanaihara; Natasha Caplen; Elise Bowman; Masahiro Seike; Kensuke Kumamoto; Ming Yi; Robert M Stephens; Aikou Okamoto; Jun Yokota; Tadao Tanaka; George Adrian Calin; Chang-Gong Liu; Carlo M Croce; Curtis C Harris
Journal: Cancer Cell Date: 2006-03 Impact factor: 31.743

5. Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

Authors: Perihan Nalbant; Yuan-Chen Chang; Jörg Birkenfeld; Zee-Fen Chang; Gary M Bokoch
Journal: Mol Biol Cell Date: 2009-07-22 Impact factor: 4.138

6. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

Authors: Aaron J Schetter; Suet Yi Leung; Jane J Sohn; Krista A Zanetti; Elise D Bowman; Nozomu Yanaihara; Siu Tsan Yuen; Tsun Leung Chan; Dora L W Kwong; Gordon K H Au; Chang-Gong Liu; George A Calin; Carlo M Croce; Curtis C Harris
Journal: JAMA Date: 2008-01-30 Impact factor: 56.272

Review 7. RhoA can lead the way in tumor cell invasion and metastasis.

Authors: Amanda P Struckhoff; Manish K Rana; Rebecca A Worthylake
Journal: Front Biosci (Landmark Ed) Date: 2011-01-01

8. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth.

Authors: Xiaohong Wang; Shuang Tang; Shu-Yun Le; Robert Lu; Janet S Rader; Craig Meyers; Zhi-Ming Zheng
Journal: PLoS One Date: 2008-07-02 Impact factor: 3.240

9. Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer.

Authors: Kristina Schee; Kjetil Boye; Torveig Weum Abrahamsen; Øystein Fodstad; Kjersti Flatmark
Journal: BMC Cancer Date: 2012-11-02 Impact factor: 4.430

10. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.

Authors: Yoshimasa Saito; Jeffrey M Friedman; Yoshitomo Chihara; Gerda Egger; Jody C Chuang; Gangning Liang
Journal: Biochem Biophys Res Commun Date: 2008-12-29 Impact factor: 3.322

27 in total

1. MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting Sirt1.

Authors: Jian-Qiang Xu; Ping Liu; Ming-Jue Si; Xiao-Yi Ding
Journal: Tumour Biol Date: 2013-07-24

Review 2. An update on miRNAs as biological and clinical determinants in colorectal cancer: a bench-to-bedside approach.

Authors: Wenhao Weng; Junlan Feng; Huanlong Qin; Yanlei Ma; Ajay Goel
Journal: Future Oncol Date: 2015 Impact factor: 3.404

3. Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells.

Authors: F Akbari Moqadam; J M Boer; E A M Lange-Turenhout; R Pieters; M L den Boer
Journal: Leukemia Date: 2013-10-23 Impact factor: 11.528

4. miR-126: A novel regulator in colon cancer.

Authors: Weina Huang; Jie Lin; Hongxuan Zhang
Journal: Biomed Rep Date: 2015-12-02

5. MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K/AKT signaling pathway.

Authors: Zheng-Chao Nie; Wen-Hao Weng; Yu-Shan Shang; Yin Long; Jing Li; Yan-Ting Xu; Zhi Li
Journal: Int J Clin Exp Pathol Date: 2015-05-01

Review 6. The roles of microRNAs related with progression and metastasis in human cancers.

Authors: Hai-Ting Liu; Peng Gao
Journal: Tumour Biol Date: 2016-10-06

7. Overexpression and knockout of miR-126 both promote leukemogenesis.

Authors: Zejuan Li; Ping Chen; Rui Su; Yuanyuan Li; Chao Hu; Yungui Wang; Stephen Arnovitz; Miao He; Sandeep Gurbuxani; Zhixiang Zuo; Abdel G Elkahloun; Shenglai Li; Hengyou Weng; Hao Huang; Mary Beth Neilly; Shusheng Wang; Eric N Olson; Richard A Larson; Michelle M Le Beau; Jiwang Zhang; Xi Jiang; Minjie Wei; Jie Jin; Paul P Liu; Jianjun Chen
Journal: Blood Date: 2015-09-11 Impact factor: 22.113

8. Long non-coding RNA LNC01133 promotes the tumorigenesis of ovarian cancer by sponging miR-126.

Authors: Bing Hou; Xiaoling Hou; Hailai Ni
Journal: Int J Clin Exp Pathol Date: 2018-12-01

Review 9. MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer.

Authors: Jian Wang; Yong Du; Xiaoming Liu; William C Cho; Yinxue Yang
Journal: Biomed Res Int Date: 2015-05-06 Impact factor: 3.411

10. RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren's disease.

Authors: Scott M Riester; Diren Arsoy; Emily T Camilleri; Amel Dudakovic; Christopher R Paradise; Jared M Evans; Jorge Torres-Mora; Marco Rizzo; Peter Kloen; Marianna Kruithof-de Julio; Andre J van Wijnen; Sanjeev Kakar
Journal: BMC Med Genomics Date: 2015-10-07 Impact factor: 3.063