Principles and applications of GFT projection NMR spectroscopy.

The two defining features of G-matrix Fourier transform (GFT) projection NMR spectroscopy are (i) repeated joint sampling of several indirect chemical shift evolution periods of a multidimensional NMR experiment so that transfer amplitudes are generated which are proportional to all possible permutations of cosine and sine modulations of the individual shifts, and (ii) linear combination of the subspectra resulting from such repeated joint sampling in the time or frequency domain which yields edited subspectra containing signals encoding phase-sensitively detected linear combinations of the jointly sampled shifts. This review sketches the underlying principles of GFT NMR and outlines its relation to further developments such as the reconstruction of multidimensional NMR spectra. Copyright 2006 John Wiley & Sons, Ltd.