| Literature DB >> 16825336 |
Marzia M Giuliani1, Jeannette Adu-Bobie, Maurizio Comanducci, Beatrice Aricò, Silvana Savino, Laura Santini, Brunella Brunelli, Stefania Bambini, Alessia Biolchi, Barbara Capecchi, Elena Cartocci, Laura Ciucchi, Federica Di Marcello, Francesca Ferlicca, Barbara Galli, Enrico Luzzi, Vega Masignani, Davide Serruto, Daniele Veggi, Mario Contorni, Maurizio Morandi, Alessandro Bartalesi, Vanda Cinotti, Donatella Mannucci, Francesca Titta, Elisa Ovidi, Jo Anne Welsch, Dan Granoff, Rino Rappuoli, Mariagrazia Pizza.
Abstract
Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90% and above by the addition of CpG oligonucleotides or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16825336 PMCID： PMC2047628 DOI： 10.1073/pnas.0603940103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205