Marwan Ghosn1, Joseph Kattan, Fadi Farhat, Fariha Younes, Jamal Gasmi. 1. Department of Oncology-Hematology, Hôtel-Dieu de France University Hospital, Achrafieh, Blvd Alfred Naccache, P.O. Box: 166830, Beirut, Lebanon, France. drghosn@sodetel.net.lb
Abstract
BACKGROUND: Vinorelbine is one of the most active cytotoxic agents in metastatic breast cancer. Its association with 5-Fluorouracil generates objective responses, varying between 44 and 55%, and improves the tolerance profile. The aim of this multicenter phase II trial was to assess the combination of capecitabine and vinorelbine as first-line chemotherapy in patients with metastatic breast cancer (MBC). PATIENTS AND METHODS: Thirty patients with MBC received a 3-week cycle combining capecitabine 825 mg/m2 twice a day on days 1 through 14, with 25 mg/m2 of vinorelbine on days 1 and 8. Treatment continued until progression, unacceptable toxicity or patient refusal to continue. The median age was 54 years (30-77) and the median WHO-PS was 1. Twenty patients (67%) received adjuvant chemotherapy including anthracycline and taxanes. RESULTS: Objective responses occurred in 21 patients (70%). Stable disease lasting more than 6 months was observed in six patients (20%). The clinical benefit rate was 90%. The median progression-free survival and overall survival were 10 months and 30.4 months, respectively. The most frequent treatment-related toxicities were: WHO grades 3 and 4 neutropenia (two patients), febrile neutropenia (two patients), grade 3 asthenia (two patients) and grade 3 nausea/vomiting (one patient). No grade 3 hand-foot syndrome was observed. CONCLUSION: The combination of capecitabine and vinorelbine is an active and safe regimen for first-line treatment of MBC.
BACKGROUND:Vinorelbine is one of the most active cytotoxic agents in metastatic breast cancer. Its association with 5-Fluorouracil generates objective responses, varying between 44 and 55%, and improves the tolerance profile. The aim of this multicenter phase II trial was to assess the combination of capecitabine and vinorelbine as first-line chemotherapy in patients with metastatic breast cancer (MBC). PATIENTS AND METHODS: Thirty patients with MBC received a 3-week cycle combining capecitabine 825 mg/m2 twice a day on days 1 through 14, with 25 mg/m2 of vinorelbine on days 1 and 8. Treatment continued until progression, unacceptable toxicity or patient refusal to continue. The median age was 54 years (30-77) and the median WHO-PS was 1. Twenty patients (67%) received adjuvant chemotherapy including anthracycline and taxanes. RESULTS: Objective responses occurred in 21 patients (70%). Stable disease lasting more than 6 months was observed in six patients (20%). The clinical benefit rate was 90%. The median progression-free survival and overall survival were 10 months and 30.4 months, respectively. The most frequent treatment-related toxicities were: WHO grades 3 and 4 neutropenia (two patients), febrile neutropenia (two patients), grade 3 asthenia (two patients) and grade 3 nausea/vomiting (one patient). No grade 3 hand-foot syndrome was observed. CONCLUSION: The combination of capecitabine and vinorelbine is an active and safe regimen for first-line treatment of MBC.
Authors: Simon P Gampenrieder; Rupert Bartsch; Peter Matzneller; Ursula Pluschnig; Peter Dubsky; Michael X Gnant; Christoph C Zielinski; Guenther G Steger Journal: Breast Care (Basel) Date: 2010-05-27 Impact factor: 2.860
Authors: Volkmar Müller; Christoph Thomssen; Marcus Schmidt; Manfred Glados; Christian Jackisch; Volker Heilmann; Axel Hinke; Antje Lehnert; Henryk Borowicz; Volker Möbus Journal: BMC Cancer Date: 2010-08-16 Impact factor: 4.430
Authors: N Tubiana-Mathieu; P Bougnoux; D Becquart; A Chan; P-F Conte; F Majois; M Espie; M Morand; N Vaissiere; G Villanova Journal: Br J Cancer Date: 2009-07-07 Impact factor: 7.640