OBJECTIVE: Problems with inhibiting certain pathological behaviors are integral to obsessive-compulsive disorder (OCD), trichotillomania, and other putative obsessive-compulsive spectrum disorders. The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge. METHOD: The Stop-Signal Task and the Intradimensiona/Extradimensional Shift Task were administered to 20 patients with OCD, 17 patients with trichotillomania, and 20 healthy comparison subjects. RESULTS: Both OCD and trichotillomania showed impaired inhibition of motor responses. For trichotillomania, the deficit was worse than for OCD, and the degree of the deficit correlated significantly with symptom severity. Only patients with OCD showed deficits in cognitive flexibility. CONCLUSIONS: Impaired inhibition of motor responses (impulsivity) was found in OCD and trichotillomania, whereas cognitive inflexibility (thought to contribute to compulsivity) was limited to OCD. This assessment will advance the characterization and classification of obsessive-compulsive spectrum disorders and aid the development of novel treatments.
OBJECTIVE: Problems with inhibiting certain pathological behaviors are integral to obsessive-compulsive disorder (OCD), trichotillomania, and other putative obsessive-compulsive spectrum disorders. The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge. METHOD: The Stop-Signal Task and the Intradimensiona/Extradimensional Shift Task were administered to 20 patients with OCD, 17 patients with trichotillomania, and 20 healthy comparison subjects. RESULTS: Both OCD and trichotillomania showed impaired inhibition of motor responses. For trichotillomania, the deficit was worse than for OCD, and the degree of the deficit correlated significantly with symptom severity. Only patients with OCD showed deficits in cognitive flexibility. CONCLUSIONS: Impaired inhibition of motor responses (impulsivity) was found in OCD and trichotillomania, whereas cognitive inflexibility (thought to contribute to compulsivity) was limited to OCD. This assessment will advance the characterization and classification of obsessive-compulsive spectrum disorders and aid the development of novel treatments.
Authors: Jennifer C Britton; Scott L Rauch; Isabelle M Rosso; William D S Killgore; Lauren M Price; Jennifer Ragan; Anne Chosak; Dianne M Hezel; Daniel S Pine; Ellen Leibenluft; David L Pauls; Michael A Jenike; S Evelyn Stewart Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-06-29 Impact factor: 8.829
Authors: Samuel R Chamberlain; Jon E Grant; Anna Costa; Ulrich Müller; Barbara J Sahakian Journal: Psychopharmacology (Berl) Date: 2010-08-17 Impact factor: 4.530
Authors: David C Houghton; Scott N Compton; Michael P Twohig; Stephen M Saunders; Martin E Franklin; Angela M Neal-Barnett; Laura Ely; Matthew R Capriotti; Douglas W Woods Journal: Psychiatry Res Date: 2014-08-13 Impact factor: 3.222