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Literature DB >> 16815577

Blood substitutes based on nanobiotechnology.

Abstract

Stimulated by concerns of potential infective agents in donated blood, commercial enterprises have attempted to develop blood substitutes since the 1900s. After several years of development, a few of the many leads are showing promise. In this article, nanobiotechnological approaches that are now in phase III clinical trials are reviewed, followed by a discussion of how important basic knowledge gained is being used to develop new generations of blood substitutes based on nanobiotechnology.

Mesh：

Substances：
Blood Substitutes

Year: 2006 PMID： 16815577 DOI： 10.1016/j.tibtech.2006.06.005

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

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Cited

10 in total

1. The immunological properties of stroma-free polyhemolysate containing catalase and superoxide dismutase activities prepared by polymerized bovine stroma-free hemolysate.

Authors: Hongli Zhu; Qianqian Du; Chao Chen; Thomas Ming Swi Chang
Journal: Artif Cells Blood Substit Immobil Biotechnol Date: 2010-04

2. 2017 Military Supplement: Hemoglobin-based Oxygen Carriers: Current State-of-the-Art and Novel Molecules.

Authors: Anirban Sen Gupta
Journal: Shock Date: 2017-09-29 Impact factor: 3.454

3. Development of a method to produce hemoglobin in a bioreactor culture of Escherichia coli BL21(DE3) transformed with a plasmid containing Plesiomonas shigelloides heme transport genes and modified human hemoglobin genes.

Authors: B J Z Smith; P Gutierrez; E Guerrero; C J Brewer; D P Henderson
Journal: Appl Environ Microbiol Date: 2011-07-29 Impact factor: 4.792

Review 4. Bio-inspired nanomedicine strategies for artificial blood components.

Authors: Anirban Sen Gupta
Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol Date: 2017-03-15

5. Quantitative analysis of hemoglobin content in polymeric nanoparticles as blood substitutes using Fourier transform infrared spectroscopy.

Authors: Xiaoqian Shan; Ligen Chen; Yuan Yuan; Changsheng Liu; Xiaolan Zhang; Yan Sheng; Feng Xu
Journal: J Mater Sci Mater Med Date: 2010-01 Impact factor: 3.896

6. Enhancement of recombinant hemoglobin production in Escherichia coli BL21(DE3) containing the Plesiomonas shigelloides heme transport system.

Authors: D M Villarreal; C L Phillips; A M Kelley; S Villarreal; A Villaloboz; P Hernandez; J S Olson; D P Henderson
Journal: Appl Environ Microbiol Date: 2008-08-01 Impact factor: 4.792

Blood substitutes based on nanobiotechnology.

1. The immunological properties of stroma-free polyhemolysate containing catalase and superoxide dismutase activities prepared by polymerized bovine stroma-free hemolysate.

2. 2017 Military Supplement: Hemoglobin-based Oxygen Carriers: Current State-of-the-Art and Novel Molecules.

3. Development of a method to produce hemoglobin in a bioreactor culture of Escherichia coli BL21(DE3) transformed with a plasmid containing Plesiomonas shigelloides heme transport genes and modified human hemoglobin genes.

Review 4. Bio-inspired nanomedicine strategies for artificial blood components.

5. Quantitative analysis of hemoglobin content in polymeric nanoparticles as blood substitutes using Fourier transform infrared spectroscopy.

6. Enhancement of recombinant hemoglobin production in Escherichia coli BL21(DE3) containing the Plesiomonas shigelloides heme transport system.

7. Site-selective glycosylation of hemoglobin on Cys beta93.

8. Low modulus biomimetic microgel particles with high loading of hemoglobin.

9. Blood substitutes--the polyheme trials.

Review 10. Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility.