Literature DB >> 16815382

Are statins analogues of vitamin D?

David S Grimes1.   

Abstract

There are many reasons why the dietary-heart-cholesterol hypothesis should be questioned, and why statins might be acting in some other way to reduce the risk of coronary heart disease. Here, I propose that rather than being cholesterol-lowering drugs per se, statins act as vitamin D analogues, and explain why. This proposition is based on published observations that the unexpected and unexplained clinical benefits produced by statins have also been shown to be properties of vitamin D. It seems likely that statins activate vitamin D receptors.

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Year:  2006        PMID: 16815382     DOI: 10.1016/S0140-6736(06)68971-X

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  16 in total

1.  Regulation of calcific vascular and valvular disease by nuclear receptors.

Authors:  Tamer Sallam; Yin Tintut; Linda L Demer
Journal:  Curr Opin Lipidol       Date:  2019-10       Impact factor: 4.776

2.  The JUPITER lipid lowering trial and vitamin D: Is there a connection?

Authors:  William R Ware
Journal:  Dermatoendocrinol       Date:  2010-04

3.  The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial.

Authors:  M D Witham; F J Dove; M Dryburgh; J A Sugden; A D Morris; A D Struthers
Journal:  Diabetologia       Date:  2010-07-02       Impact factor: 10.122

4.  Vitamin D is associated with atheroprotective high-density lipoprotein profile in postmenopausal women.

Authors:  Rasa Kazlauskaite; Lynda H Powell; Chaitanya Mandapakala; John F Cursio; Elizabeth F Avery; James Calvin
Journal:  J Clin Lipidol       Date:  2010-02-06       Impact factor: 4.766

Review 5.  Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research.

Authors:  Amir A Zeki; Nicholas J Kenyon; Tzipora Goldkorn
Journal:  Drug Metab Lett       Date:  2011-01

6.  Statins and vitamin D: a friendly association in pre-dialysis patients.

Authors:  Pedro L Neves; Anabela Malho; Ana Cabrita; Ana Pinho; Alexandre Baptista; Elsa Morgado; Marília Faísca; Hermínio Carrasqueira; Ana P Silva
Journal:  Int Urol Nephrol       Date:  2009-09-11       Impact factor: 2.370

7.  Vitamin D, race, and cardiovascular mortality: findings from a national US sample.

Authors:  Kevin Fiscella; Peter Franks
Journal:  Ann Fam Med       Date:  2010 Jan-Feb       Impact factor: 5.166

8.  Different cardiometabolic effects of atorvastatin in men with normal vitamin D status and vitamin D insufficiency.

Authors:  Robert Krysiak; Małgorzata Gilowska; Bogusław Okopień
Journal:  Clin Cardiol       Date:  2016-09-26       Impact factor: 2.882

9.  Atherosclerosis, cholesterol, nutrition, and statins--a critical review.

Authors:  Jan-Olaf Gebbers
Journal:  Ger Med Sci       Date:  2007-08-16

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063

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