Kevin Fiscella1, Peter Franks. 1. Department of Family Medicine and Department of Community & Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Kevin_Fiscella@URMC.rochester.edu
Abstract
PURPOSE: Findings are conflicting about the relationship between vitamin D levels and cardiovascular mortality. We wanted to determine the contribution of vitamin D levels to black-white disparities in cardiovascular mortality. METHODS: We examined the association of serum 25(OH)D levels with cardiovascular mortality and its contribution to elevated risk among blacks through a retrospective cohort using baseline data from the third National Health and Nutrition Examination Survey 1988-1994 and cause-specific mortality through 2001 using the National Death Index. Using piecewise Poisson regression models, we examined the risk of cardiovascular death (coronary heart disease, heart failure, and stroke) by sample 25(OH)D quartile, adjusting for cardiovascular risk factors, and compared models of adjusted race-related cardiovascular mortality with and without further adjustment for 25(OH)D levels. RESULTS: Participants with 25(OH)D levels in the lowest quartile (mean = 13.9 ng/mL) compared with those in the 3 higher quartiles (mean = 21.6, 28.4, and 41.6 ng/mL) had higher adjusted risk of cardiovascular death (incident rate ratio [IRR] = 1.40; 95% confidence interval [CI], 1.16-1.70). The higher age- and sex-adjusted cardiovascular mortality observed in blacks vs whites (IRR = 1.38; 95% CI, 1.13-1.70) was attenuated (IRR = 1.14; 95% CI, 0.91-1.44) by adjustment for 25(OH)D levels and fully eliminated with further adjustment for income (IRR=1.01; 95% CI, 0.82-1.24). CONCLUSIONS: Low serum levels of 25(OH)D are associated with increased cardiovascular mortality in a nationally representative US sample. Black-white differences in 25(OH)D levels may contribute to excess cardiovascular mortality in blacks. Interventional trials among persons with low vitamin D levels are needed to determine whether oral supplementation improves cardiovascular outcomes.
PURPOSE: Findings are conflicting about the relationship between vitamin D levels and cardiovascular mortality. We wanted to determine the contribution of vitamin D levels to black-white disparities in cardiovascular mortality. METHODS: We examined the association of serum 25(OH)D levels with cardiovascular mortality and its contribution to elevated risk among blacks through a retrospective cohort using baseline data from the third National Health and Nutrition Examination Survey 1988-1994 and cause-specific mortality through 2001 using the National Death Index. Using piecewise Poisson regression models, we examined the risk of cardiovascular death (coronary heart disease, heart failure, and stroke) by sample 25(OH)D quartile, adjusting for cardiovascular risk factors, and compared models of adjusted race-related cardiovascular mortality with and without further adjustment for 25(OH)D levels. RESULTS:Participants with 25(OH)D levels in the lowest quartile (mean = 13.9 ng/mL) compared with those in the 3 higher quartiles (mean = 21.6, 28.4, and 41.6 ng/mL) had higher adjusted risk of cardiovascular death (incident rate ratio [IRR] = 1.40; 95% confidence interval [CI], 1.16-1.70). The higher age- and sex-adjusted cardiovascular mortality observed in blacks vs whites (IRR = 1.38; 95% CI, 1.13-1.70) was attenuated (IRR = 1.14; 95% CI, 0.91-1.44) by adjustment for 25(OH)D levels and fully eliminated with further adjustment for income (IRR=1.01; 95% CI, 0.82-1.24). CONCLUSIONS: Low serum levels of 25(OH)D are associated with increased cardiovascular mortality in a nationally representative US sample. Black-white differences in 25(OH)D levels may contribute to excess cardiovascular mortality in blacks. Interventional trials among persons with low vitamin D levels are needed to determine whether oral supplementation improves cardiovascular outcomes.
Authors: Paul G Shekelle; Sally C Morton; Lara K Jungvig; Jay Udani; Myles Spar; Wenli Tu; Marika J Suttorp; Ian Coulter; Sydne J Newberry; Mary Hardy Journal: J Gen Intern Med Date: 2004-04 Impact factor: 5.128
Authors: Kumaravel Rajakumar; John D Fernstrom; Michael F Holick; Janine E Janosky; Susan L Greenspan Journal: Obesity (Silver Spring) Date: 2008-01 Impact factor: 5.002
Authors: Lisa B Signorello; Scott M Williams; Wei Zheng; Jeffrey R Smith; Jirong Long; Qiuyin Cai; Margaret K Hargreaves; Bruce W Hollis; William J Blot Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-07-20 Impact factor: 4.254
Authors: Daniel V Dudenkov; Kristin C Mara; Tanya M Petterson; Julie A Maxson; Tom D Thacher Journal: Mayo Clin Proc Date: 2018-05-02 Impact factor: 7.616
Authors: Rebecca S Boxer; Anne M Kenny; Vinay K Cheruvu; Marianne Vest; Justin J Fiutem; Ileana I Piña Journal: Am Heart J Date: 2010-11 Impact factor: 4.749
Authors: Kimmie Ng; Jamil B Scott; Bettina F Drake; Andrew T Chan; Bruce W Hollis; Paulette D Chandler; Gary G Bennett; Edward L Giovannucci; Elizabeth Gonzalez-Suarez; Jeffrey A Meyerhardt; Karen M Emmons; Charles S Fuchs Journal: Am J Clin Nutr Date: 2013-12-24 Impact factor: 7.045
Authors: Michelle Y O'Connor; Caroline K Thoreson; Natalie L M Ramsey; Madia Ricks; Anne E Sumner Journal: Prog Cardiovasc Dis Date: 2013 Nov-Dec Impact factor: 8.194
Authors: Daniel V Dudenkov; Barbara P Yawn; Sara S Oberhelman; Philip R Fischer; Ravinder J Singh; Stephen S Cha; Julie A Maxson; Stephanie M Quigg; Tom D Thacher Journal: Mayo Clin Proc Date: 2015-05 Impact factor: 7.616
Authors: Mariam Aziz; Britt Livak; Jane Burke-Miller; Audrey L French; Marshall J Glesby; Anjali Sharma; Mary Young; Maria C Villacres; Phyllis C Tien; Elizabeth T Golub; Mardge H Cohen; Oluwatoyin M Adeyemi Journal: AIDS Date: 2013-02-20 Impact factor: 4.177