Literature DB >> 168074

Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells.

J Content, B Lebleu, U Nudel, A Zilberstein, H Berissi, M Revel.   

Abstract

Synthesis of polypeptide chains coded by exogenous messenger RNAs is inhibited in cell-free extracts from interferon-treated mouse L cells, due to a "deficiency" in some specific tRNA species. A detailed analysis shows that polypeptide chain elongation is blocked and incomplete chains are formed. After a few minutes, however, initiation of new polypeptide chains is also blocked. Messenger RNA still binds to ribosomes but initiator Met-tRNA(FMET) binding is inhibited. The block in initiation appears to be secondary to the block in elongation.

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Year:  1975        PMID： 168074     DOI： 10.1111/j.1432-1033.1975.tb04106.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  11 in total

1.  Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.

Authors:  A G Hovanessian; J Wood; E Meurs; L Montagnier
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  An interferon-induced phosphodiesterase degrading (2'-5') oligoisoadenylate and the C-C-A terminus of tRNA.

Authors:  A Schmidt; Y Chernajovsky; L Shulman; P Federman; H Berissi; M Revel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

3.  Specificity of interferon action in protein synthesis.

Authors:  P M Yau; T Godefroy-Colburn; C H Birge; T V Ramabhadran; R E Thach
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

Review 4.  Antiviral activity of interferons.

Authors:  R M Friedman
Journal:  Bacteriol Rev       Date:  1977-09

Review 5.  The interferon renaissance: molecular aspects of induction and action.

Authors:  J Gordon; M A Minks
Journal:  Microbiol Rev       Date:  1981-06

6.  Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.

Authors:  A Zilberstein; A Kimchi; A Schmidt; M Revel
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

7.  RNase activity in human interferon preparations.

Authors:  R A Winchurch; T P Karpetsky; C C Levy; K Cantell
Journal:  J Virol       Date:  1977-03       Impact factor: 5.103

8.  Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase.

Authors:  C E Samuel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

9.  RNA methylation in vaccinia virus-infected chick embryo fibroblasts treated with homologous interferon.

Authors:  H Kroath; H J Gross; C Jungwirth; G Bodo
Journal:  Nucleic Acids Res       Date:  1978-07       Impact factor: 16.971

10.  Oligonucleotide inhibitor of protein synthesis made in extracts of interferon-treated chick embryo cells: comparison with the mouse low molecular weight inhibitor.

Authors:  L A Ball; C N White
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205
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