Songmao Zhang1, Olivier Bodenreider. 1. U. S. National Library of Medicine, Bethesda, Maryland, National Institutes of Health, Department of Health & Human Services, USA. smhang@math.ac.cn
Abstract
OBJECTIVE: To investigate the indirect alignment of two anatomical ontologies through a reference ontology and to compare it to direct alignment between these two ontologies. The ontologies under investigation are the Adult Mouse Anatomical Dictionary (MA) and the NCI Thesaurus (NCI). The Foundational Model of Anatomy serves as reference ontology. METHODS: The direct alignment employs a combination of lexical and structural similarity. The indirect alignment simply derives mappings from direct alignments to the reference ontology. RESULTS: The indirect MA-NCI alignment yielded 703 mappings and the direct alignment 715, 654 of which are common to both. The mappings specific to one approach were analyzed. CONCLUSIONS: When a reference ontology exists, indirect alignment of multiple ontologies through a reference represents a valid, cost-effective alternative to pairwise alignment.
OBJECTIVE: To investigate the indirect alignment of two anatomical ontologies through a reference ontology and to compare it to direct alignment between these two ontologies. The ontologies under investigation are the Adult Mouse Anatomical Dictionary (MA) and the NCI Thesaurus (NCI). The Foundational Model of Anatomy serves as reference ontology. METHODS: The direct alignment employs a combination of lexical and structural similarity. The indirect alignment simply derives mappings from direct alignments to the reference ontology. RESULTS: The indirect MA-NCI alignment yielded 703 mappings and the direct alignment 715, 654 of which are common to both. The mappings specific to one approach were analyzed. CONCLUSIONS: When a reference ontology exists, indirect alignment of multiple ontologies through a reference represents a valid, cost-effective alternative to pairwise alignment.
Authors: William J Bug; Giorgio A Ascoli; Jeffrey S Grethe; Amarnath Gupta; Christine Fennema-Notestine; Angela R Laird; Stephen D Larson; Daniel Rubin; Gordon M Shepherd; Jessica A Turner; Maryann E Martone Journal: Neuroinformatics Date: 2008-10-31
Authors: George A Komatsoulis; Denise B Warzel; Francis W Hartel; Krishnakant Shanbhag; Ram Chilukuri; Gilberto Fragoso; Sherri de Coronado; Dianne M Reeves; Jillaine B Hadfield; Christophe Ludet; Peter A Covitz Journal: J Biomed Inform Date: 2007-04-02 Impact factor: 6.317