OBJECTIVES: To develop standardized definitions for classification of partial seizure symptoms for use in genetic research on the epilepsies, and evaluate inter-rater reliability of classifications based on these definitions. METHODS: The authors developed the Partial Seizure Symptom Definitions (PSSD), which include standardized definitions of 41 partial seizure symptoms within the sensory, autonomic, aphasic, psychic, and motor categories. Based on these definitions, two epileptologists independently classified partial seizures in 75 individuals from 34 families selected because one person had ictal auditory symptoms or aphasia. The data used for classification consisted of standardized diagnostic interviews with subjects and family informants, and medical records obtained from treating neurologists. Agreement was assessed by kappa. RESULTS: Agreement between the two neurologists using the PSSD was "substantial" or "almost perfect" for most symptom categories. CONCLUSIONS: Use of standardized definitions for classification of partial seizure symptoms such as those in the Partial Seizure Symptom Definitions should improve reliability and accuracy in future genetic studies of the epilepsies.
OBJECTIVES: To develop standardized definitions for classification of partial seizure symptoms for use in genetic research on the epilepsies, and evaluate inter-rater reliability of classifications based on these definitions. METHODS: The authors developed the Partial Seizure Symptom Definitions (PSSD), which include standardized definitions of 41 partial seizure symptoms within the sensory, autonomic, aphasic, psychic, and motor categories. Based on these definitions, two epileptologists independently classified partial seizures in 75 individuals from 34 families selected because one person had ictal auditory symptoms or aphasia. The data used for classification consisted of standardized diagnostic interviews with subjects and family informants, and medical records obtained from treating neurologists. Agreement was assessed by kappa. RESULTS: Agreement between the two neurologists using the PSSD was "substantial" or "almost perfect" for most symptom categories. CONCLUSIONS: Use of standardized definitions for classification of partial seizure symptoms such as those in the Partial Seizure Symptom Definitions should improve reliability and accuracy in future genetic studies of the epilepsies.
Authors: José M Morante-Redolat; Ana Gorostidi-Pagola; Salomé Piquer-Sirerol; Amets Sáenz; Juan J Poza; Juan Galán; Stefan Gesk; Theologia Sarafidou; Victor-F Mautner; Simona Binelli; Eike Staub; Bernd Hinzmann; Lisa French; Jean-F Prud'homme; Daniela Passarelli; Paolo Scannapieco; Carlo A Tassinari; Giuliano Avanzini; José F Martí-Massó; Lan Kluwe; Panagiotis Deloukas; Nicholas K Moschonas; Roberto Michelucci; Reiner Siebert; Carlo Nobile; Jordi Pérez-Tur; Adolfo López de Munain Journal: Hum Mol Genet Date: 2002-05-01 Impact factor: 6.150
Authors: R Ottman; M R Winawer; S Kalachikov; C Barker-Cummings; T C Gilliam; T A Pedley; W A Hauser Journal: Neurology Date: 2004-04-13 Impact factor: 9.910
Authors: Gary A Heiman; Kay Kamberakis; Richard Gill; Sergey Kalachikov; Timothy A Pedley; W Allen Hauser; Ruth Ottman Journal: Epilepsia Date: 2010-07-26 Impact factor: 5.864
Authors: Heejong Sung; Fei Ji; Deborah L Levy; Steven Matthysse; Nancy Role Mendell Journal: Comput Stat Data Anal Date: 2009-03-15 Impact factor: 1.681
Authors: A Poduri; Y Wang; D Gordon; S Barral-Rodriguez; C Barker-Cummings; A Ulgen; V Chitsazzadeh; R S Hill; N Risch; W A Hauser; T A Pedley; C A Walsh; R Ottman Journal: Neurology Date: 2009-10-20 Impact factor: 9.910
Authors: Laura Rigon; Andrea Vettori; Giorgia Busolin; Gabriella Egeo; Patrizia Pulitano; Lia Santulli; Elena Pasini; Pasquale Striano; Angela la Neve; Valeria Vianello Dri; Clementina Boniver; Antonio Gambardella; Paola Banfi; Simona Binelli; Carlo Di Bonaventura; Salvatore Striano; Fabrizio de Falco; Anna T Giallonardo; Oriano Mecarelli; Roberto Michelucci; Carlo Nobile Journal: Epilepsy Res Treat Date: 2010-12-21