Patricia Dugan1, Chad Carlson2, Judith Bluvstein2, Derek J Chong2, Daniel Friedman2, Heidi E Kirsch2. 1. From the Department of Neurology (P.D., J.B., D.J.C., D.F.), New York University Langone Medical Center, New York; Department of Neurology (C.C.), Medical College of Wisconsin, Milwaukee; and Department of Neurology (H.E.K.), University of California, San Francisco. patricia.dugan@nyumc.org. 2. From the Department of Neurology (P.D., J.B., D.J.C., D.F.), New York University Langone Medical Center, New York; Department of Neurology (C.C.), Medical College of Wisconsin, Milwaukee; and Department of Neurology (H.E.K.), University of California, San Francisco.
Abstract
OBJECTIVE: We studied the frequency of auras in generalized epilepsy (GE) using a detailed semistructured diagnostic interview. METHODS: In this cross-sectional study, participants with GE were drawn from the Epilepsy Phenome/Genome Project (EPGP). Responses to the standardized diagnostic interview regarding tonic-clonic (grand mal) seizures were then examined. This questionnaire initially required participants to provide their own description of any subjective phenomena before their "grand mal seizures." Participants who provided answers to these questions were considered to have an aura. All participants were then systematically queried regarding a list of specific symptoms occurring before grand mal seizures, using structured (closed-ended) questions. RESULTS: Seven hundred ninety-eight participants with GE were identified, of whom 530 reported grand mal seizures. Of these, 112 (21.3%) reported auras in response to the open-ended question. Analysis of responses to the closed-ended questions suggested that 341 participants (64.3%) experienced at least one form of aura. CONCLUSIONS: Auras typically associated with focal epilepsy were reported by a substantial proportion of EPGP subjects with GE. This finding may support existing theories of cortical and subcortical generators of GE with variable spread patterns. Differences between responses to the open-ended question and closed-ended questions may also reflect clinically relevant variation in patient responses to history-taking and surveys. Open-ended questions may underestimate the prevalence of specific types of auras and may be in part responsible for the underrecognition of auras in GE. In addition, structured questions may influence participants, possibly leading to a greater representation of symptoms.
OBJECTIVE: We studied the frequency of auras in generalized epilepsy (GE) using a detailed semistructured diagnostic interview. METHODS: In this cross-sectional study, participants with GE were drawn from the Epilepsy Phenome/Genome Project (EPGP). Responses to the standardized diagnostic interview regarding tonic-clonic (grand mal) seizures were then examined. This questionnaire initially required participants to provide their own description of any subjective phenomena before their "grand mal seizures." Participants who provided answers to these questions were considered to have an aura. All participants were then systematically queried regarding a list of specific symptoms occurring before grand mal seizures, using structured (closed-ended) questions. RESULTS: Seven hundred ninety-eight participants with GE were identified, of whom 530 reported grand mal seizures. Of these, 112 (21.3%) reported auras in response to the open-ended question. Analysis of responses to the closed-ended questions suggested that 341 participants (64.3%) experienced at least one form of aura. CONCLUSIONS:Auras typically associated with focal epilepsy were reported by a substantial proportion of EPGP subjects with GE. This finding may support existing theories of cortical and subcortical generators of GE with variable spread patterns. Differences between responses to the open-ended question and closed-ended questions may also reflect clinically relevant variation in patient responses to history-taking and surveys. Open-ended questions may underestimate the prevalence of specific types of auras and may be in part responsible for the underrecognition of auras in GE. In addition, structured questions may influence participants, possibly leading to a greater representation of symptoms.
Authors: C P Panayiotopoulos; E Chroni; C Daskalopoulos; A Baker; S Rowlinson; P Walsh Journal: J Neurol Neurosurg Psychiatry Date: 1992-11 Impact factor: 10.154
Authors: Prisca R Bauer; Else A Tolner; Mark R Keezer; Michel D Ferrari; Josemir W Sander Journal: Nat Rev Neurol Date: 2021-07-26 Impact factor: 42.937
Authors: Jerzy P Szaflarski; Seongtaek Lee; Jane B Allendorfer; Tyler E Gaston; Robert C Knowlton; Sandipan Pati; Lawrence W Ver Hoef; Georg Deutsch Journal: Med Sci Monit Date: 2016-06-10
Authors: Yongxing Zhou; Raman Sood; Qun Wang; Blake Carrington; Morgan Park; Alice C Young; Daniel Birnbaum; Zhao Liu; Tetsuo Ashizawa; James C Mullikin; Mohamad Z Koubeissi; Paul Liu Journal: Epilepsia Open Date: 2021-02-02