| Literature DB >> 16759797 |
Yinghao Su1, Stella Davies, Mary Davis, Hua Lu, Roger Giller, Mark Krailo, Qiuyin Cai, Leslie Robison, Xiao-Ou Shu.
Abstract
The long interspersed nucleotide element-1 (LINE-1) p40 protein was expressed in all 162 cases of childhood malignant germ cell tumor (MGCT) cells with weak, moderate, and strong immunoactivity in 43.8%, 37.7%, and 18.5%, respectively. Normal testicular tissue adjacent to tumors showed negative or weaker p40 expression than tumor cells. Multivariate analyses showed that strong expression of p40 was associated with poor differentiation, extragonadal site, and the histotype of yolk sac tumor. This study suggests that the active LINE-1 retrotransposon is a common event in pediatric MGCTs and abundant expression of p40 might play a role during the malignant transformation.Entities:
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Year: 2006 PMID： 16759797 DOI： 10.1016/j.canlet.2006.04.010
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679