Literature DB >> 16741121

Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.

Anders Olsen1, Maithili C Vantipalli, Gordon J Lithgow.   

Abstract

Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

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Year:  2006        PMID： 16741121      PMCID： PMC2568993          DOI： 10.1126/science.1124981

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

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