Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A unified view of the DNA-damage checkpoint.

Literature DB >> 11891124

A unified view of the DNA-damage checkpoint.

Abstract

Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three "sensor" proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.

Entities: Gene Species

Mesh：

Substances：

Year: 2002 PMID： 11891124 DOI： 10.1016/s0955-0674(02)00312-5

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

Keyword Cloud
Cited

181 in total

1. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.

Authors: Arne S IJpma; Carol W Greider
Journal: Mol Biol Cell Date: 2003-03 Impact factor: 4.138

2. S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.

Authors: Cheryl D Warren; D Mark Eckley; Marina S Lee; Joseph S Hanna; Adam Hughes; Brian Peyser; Chunfa Jie; Rafael Irizarry; Forrest A Spencer
Journal: Mol Biol Cell Date: 2004-01-23 Impact factor: 4.138

3. Regulation of checkpoint kinases through dynamic interaction with Crb2.

Authors: Satoru Mochida; Fumiko Esashi; Nobuki Aono; Katsuyuki Tamai; Matthew J O'Connell; Mitsuhiro Yanagida
Journal: EMBO J Date: 2004-01-22 Impact factor: 11.598

4. ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.

Authors: Kenji Shimada; Philippe Pasero; Susan M Gasser
Journal: Genes Dev Date: 2002-12-15 Impact factor: 11.361

Review 5. Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.

Authors: Daniel Vlcek; Andrea Sevcovicová; Barbara Sviezená; Eliska Gálová; Eva Miadoková
Journal: Curr Genet Date: 2007-11-09 Impact factor: 3.886

A unified view of the DNA-damage checkpoint.

1. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.

2. S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.

3. Regulation of checkpoint kinases through dynamic interaction with Crb2.

4. ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.

Review 5. Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.

6. Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1.

7. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

8. The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function.

9. Uncovering novel cell cycle players through the inactivation of securin in budding yeast.

10. An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control.