| Literature DB >> 16741098 |
Matt Kaeberlein1, Kristan K Steffen, Di Hu, Nick Dang, Emily O Kerr, Mitsuhiro Tsuchiya, Stanley Fields, Brian K Kennedy.
Abstract
Calorie restriction (CR) increases life span in yeast independently of Sir2. Lamming et al. (Reports, 16 September 2005, p. 1861) recently proposed that Sir2-independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16741098 DOI： 10.1126/science.1124608
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728