Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The controversial world of sirtuins.

Literature DB >> 25027380

The controversial world of sirtuins.

Abstract

The controversy around sirtuins and their functions in aging has drawn in the past few years as much attention, if not more, from the scientific community and the public as they did when first proposed as the key conserved aging regulators in eukaryotes. With some of the basic observations on sirtuin longevity promoting functions being questioned in popular model systems, researchers are wondering if this family of conserved enzymes still holds strong potential as therapeutic targets. This review examines the several controversial issues around sirtuins and their functions in aging, calorie restriction, as well as age-related diseases in light of recent studies in mammalian systems and discusses whether modulators of sirtuins still hold the secret of life.:

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25027380 PMCID： PMC4101544 DOI： 10.1016/j.ddtec.2012.08.003

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

81 in total

1. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors: Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

2. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

Authors: Hyun-Seok Kim; Athanassios Vassilopoulos; Rui-Hong Wang; Tyler Lahusen; Zhen Xiao; Xiaoling Xu; Cuiling Li; Timothy D Veenstra; Bing Li; Hongtao Yu; Junfang Ji; Xin Wei Wang; Seong-Hoon Park; Yong I Cha; David Gius; Chu-Xia Deng
Journal: Cancer Cell Date: 2011-10-18 Impact factor: 31.743

3. SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

Authors: Julie L Huber; Michael W McBurney; Peter S Distefano; Thomas McDonagh
Journal: Future Med Chem Date: 2010-12 Impact factor: 3.808

4. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

Authors: F Wang; C-H Chan; K Chen; X Guan; H-K Lin; Q Tong
Journal: Oncogene Date: 2011-08-15 Impact factor: 9.867

Review 5. Resveratrol, sirtuins, and the promise of a DR mimetic.

Authors: Joseph A Baur
Journal: Mech Ageing Dev Date: 2010-02-26 Impact factor: 5.432

6. SIRT6 promotes DNA repair under stress by activating PARP1.

Authors: Zhiyong Mao; Christopher Hine; Xiao Tian; Michael Van Meter; Matthew Au; Amita Vaidya; Andrei Seluanov; Vera Gorbunova
Journal: Science Date: 2011-06-17 Impact factor: 47.728

7. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

8. Mechanism of human SIRT1 activation by resveratrol.

Authors: Margie T Borra; Brian C Smith; John M Denu
Journal: J Biol Chem Date: 2005-03-04 Impact factor: 5.157

9. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal: Nature Date: 2003-08-24 Impact factor: 49.962

10. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Authors: Rui-Hong Wang; Kundan Sengupta; Cuiling Li; Hyun-Seok Kim; Liu Cao; Cuiying Xiao; Sangsoo Kim; Xiaoling Xu; Yin Zheng; Beverly Chilton; Rong Jia; Zhi-Ming Zheng; Ettore Appella; Xin Wei Wang; Thomas Ried; Chu-Xia Deng
Journal: Cancer Cell Date: 2008-10-07 Impact factor: 31.743

37 in total

Review 1. Key proteins and pathways that regulate lifespan.

Authors: Haihui Pan; Toren Finkel
Journal: J Biol Chem Date: 2017-03-06 Impact factor: 5.157

Review 2. Sirtuins in Skin and Skin Cancers.

Authors: Liz Mariely Garcia-Peterson; Melissa Jean Wilking-Busch; Mary Ann Ndiaye; Christine Gaby Azer Philippe; Vijayasaradhi Setaluri; Nihal Ahmad
Journal: Skin Pharmacol Physiol Date: 2017-07-14 Impact factor: 3.479

Review 10. Autophagy and cardiac aging.

Authors: Shigeki Miyamoto
Journal: Cell Death Differ Date: 2019-01-28 Impact factor: 15.828

The controversial world of sirtuins.

1. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

2. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

3. SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

4. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

Review 5. Resveratrol, sirtuins, and the promise of a DR mimetic.

6. SIRT6 promotes DNA repair under stress by activating PARP1.

7. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

8. Mechanism of human SIRT1 activation by resveratrol.

9. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

10. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Review 1. Key proteins and pathways that regulate lifespan.

Review 2. Sirtuins in Skin and Skin Cancers.

Review 3. Cellular analysis of the action of epigenetic drugs and probes.

4. Sirtuin-1 regulates organismal growth by altering feeding behavior and intestinal morphology in planarians.

Review 5. Sirtuins in Renal Health and Disease.

6. Sirt3, 6, and 7 Genes Expression in Gastric Antral Epithelial Cells of Patients with Helicobacter pylori Infection.

7. Profiling sirtuin activity using Copper-free click chemistry.

Review 8. Sirtuin modulators: past, present, and future perspectives.

9. Association of Serum Levels of Silent Information Regulator 1 with Persistent Organ Failure in Acute Pancreatitis.

Review 10. Autophagy and cardiac aging.