Literature DB >> 16723587

Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.

Jennifer Nielsen Kahn1, Ming-Jo Hsu, Fred Racine, Robert Giacobbe, Mary Motyl.   

Abstract

Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

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Year:  2006        PMID： 16723587      PMCID： PMC1479154          DOI： 10.1128/AAC.01610-05

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

Review 1.  Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus.

Authors:  M A Pfaller; D J Diekema
Journal:  J Clin Microbiol       Date:  2004-10       Impact factor: 5.948

2.  A microtiter-based fluorescence assay for (1,3)-beta-glucan synthases.

Authors:  E Shedletzky; C Unger; D P Delmer
Journal:  Anal Biochem       Date:  1997-06-15       Impact factor: 3.365

3.  Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.

Authors:  S Park; R Kelly; J Nielsen Kahn; J Robles; M-J Hsu; E Register; W Li; V Vyas; H Fan; G Abruzzo; A Flattery; C Gill; G Chrebet; S A Parent; M Kurtz; H Teppler; C M Douglas; D S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

4.  Isolation of a gene involved in 1,3-beta-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein.

Authors:  R Kelly; E Register; M J Hsu; M Kurtz; J Nielsen
Journal:  J Bacteriol       Date:  1996-08       Impact factor: 3.490

5.  In vitro activity of anidulafungin against selected clinically important mold isolates.

Authors:  Zekaver Odabasi; Victor L Paetznick; Jose R Rodriguez; Enuo Chen; Luis Ostrosky-Zeichner
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

6.  Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.

Authors:  D J Diekema; S A Messer; R J Hollis; R N Jones; M A Pfaller
Journal:  J Clin Microbiol       Date:  2003-08       Impact factor: 5.948
  6 in total
  27 in total

1.  Profiling the Aspergillus fumigatus proteome in response to caspofungin.

Authors:  Steven E Cagas; Mohit Raja Jain; Hong Li; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2010-10-25       Impact factor: 5.191

Review 2.  Resistance to echinocandin-class antifungal drugs.

Authors:  David S Perlin
Journal:  Drug Resist Updat       Date:  2007-06-13       Impact factor: 18.500

3.  MaFKS, a β-1,3-glucan synthase, is involved in cell wall integrity, hyperosmotic pressure tolerance and conidiation in Metarhizium acridum.

Authors:  Min Yang; Kai Jin; Yuxian Xia
Journal:  Curr Genet       Date:  2011-05-12       Impact factor: 3.886

4.  Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.

Authors:  J C Bowman; G K Abruzzo; A M Flattery; C J Gill; E J Hickey; M J Hsu; J Nielsen Kahn; P A Liberator; A S Misura; B A Pelak; T C Wang; C M Douglas
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

Review 5.  Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species.

Authors:  Sharon C-A Chen; Russell E Lewis; Dimitrios P Kontoyiannis
Journal:  Virulence       Date:  2011-07-01       Impact factor: 5.882

6.  Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents.

Authors:  Wendy W J van de Sande; Ahmed H Fahal; Irma A J M Bakker-Woudenberg; Alex van Belkum
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

7.  Endoplasmic reticulum localized PerA is required for cell wall integrity, azole drug resistance, and virulence in Aspergillus fumigatus.

Authors:  Dawoon Chung; Arsa Thammahong; Kelly M Shepardson; Sara J Blosser; Robert A Cramer
Journal:  Mol Microbiol       Date:  2014-05-09       Impact factor: 3.501

8.  Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints.

Authors:  Guillermo Garcia-Effron; Steven Park; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2008-10-27       Impact factor: 5.191

9.  Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.

Authors:  Robert A Cramer; B Zachary Perfect; Nadthanan Pinchai; Steven Park; David S Perlin; Yohannes G Asfaw; Joseph Heitman; John R Perfect; William J Steinbach
Journal:  Eukaryot Cell       Date:  2008-05-02

10.  In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: a head-to-head comparison using the CLSI M38-A2 broth microdilution method.

Authors:  M A Pfaller; L Boyken; R J Hollis; J Kroeger; S A Messer; S Tendolkar; D J Diekema
Journal:  J Clin Microbiol       Date:  2009-08-26       Impact factor: 5.948
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