| Literature DB >> 16722623 |
Nareshkumar Jain1, Ramesh M Kanojia, Jiayi Xu, Guo Jian-Zhong, Emmanuel Pacia, Muh-Tsann Lai, Fuyong Du, Amy Musto, George Allan, DoWon Hahn, Scott Lundeen, Zhihua Sui.
Abstract
A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma cholesterol and bone metabolism while maintaining antiestrogenic activity in the uterus. The biological profile of its enantiomer 1-(S) was also evaluated.Entities:
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Year: 2006 PMID： 16722623 DOI： 10.1021/jm060353u
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446