Literature DB >> 24971815

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.

Ilaria Paterni1, Carlotta Granchi1, John A Katzenellenbogen2, Filippo Minutolo3.   

Abstract

Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans. Modulation of these receptors by prospective therapeutic agents is currently being considered for prevention and treatment of a wide variety of pathological conditions, such as, cancer, metabolic and cardiovascular diseases, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Agonists; Antagonists; Estrogen receptor subtype α; Estrogen receptor subtype β; Modulators; Therapeutic applications

Mesh：

Substances：

Year:  2014        PMID： 24971815      PMCID： PMC4192010          DOI： 10.1016/j.steroids.2014.06.012

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  161 in total

1.  Lead identification of a potent benzopyranone selective estrogen receptor modulator.

Authors:  Jeffrey A McKie; Shripad S Bhagwat; Helen Brady; Mary Doubleday; Leah Gayo; Mathew Hickman; Ravi K Jalluri; Sak Khammungkhune; Adam Kois; Deborah Mortensen; Normand Richard; John Sapienza; Graziella Shevlin; Bernd Stein; May Sutherland
Journal:  Bioorg Med Chem Lett       Date:  2004-07-05       Impact factor: 2.823

2.  Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand.

Authors:  Xin-jie Tan; Yu-bing Dai; Wan-fu Wu; Hyun-jin Kim; Rodrigo P A Barros; Timothy I Richardson; Benjamin C Yaden; Margaret Warner; David L McKinzie; Venkatesh Krishnan; Jan-Åke Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

Review 3.  Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents.

Authors:  V Craig Jordan
Journal:  J Med Chem       Date:  2003-03-27       Impact factor: 7.446

Review 4.  Estrogen receptors: therapies targeted to receptor subtypes.

Authors:  S Nilsson; J-Å Gustafsson
Journal:  Clin Pharmacol Ther       Date:  2010-12-01       Impact factor: 6.875

5.  Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta.

Authors:  Xiaomei Guo; Mahnaz Razandi; Ali Pedram; Ghassan Kassab; Ellis R Levin
Journal:  J Biol Chem       Date:  2005-03-11       Impact factor: 5.157

6.  β-LGND2, an ERβ selective agonist, inhibits pathologic retinal neovascularization.

Authors:  Anand Giddabasappa; Jeetendra R Eswaraka; Christina M Barrett; Matthew N Bauler; Zhongzhi Wu; Muralimohan Yepuru; Duane D Miller; James T Dalton
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-07-31       Impact factor: 4.799

7.  Soya isoflavone supplementation enhances spatial working memory in men.

Authors:  Alicia A Thorp; Natalie Sinn; Jonathan D Buckley; Alison M Coates; Peter R C Howe
Journal:  Br J Nutr       Date:  2009-06-01       Impact factor: 3.718

8.  Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Authors:  Marine Adlanmerini; Romain Solinhac; Anne Abot; Aurélie Fabre; Isabelle Raymond-Letron; Anne-Laure Guihot; Frédéric Boudou; Lucile Sautier; Emilie Vessières; Sung Hoon Kim; Philippe Lière; Coralie Fontaine; Andrée Krust; Pierre Chambon; John A Katzenellenbogen; Pierre Gourdy; Philip W Shaul; Daniel Henrion; Jean-François Arnal; Françoise Lenfant
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-26       Impact factor: 11.205

9.  Expression of oestrogen receptor β and prognosis of colorectal cancer.

Authors:  A Rudolph; C Toth; M Hoffmeister; W Roth; E Herpel; L Jansen; A Marx; H Brenner; J Chang-Claude
Journal:  Br J Cancer       Date:  2012-07-24       Impact factor: 7.640

10.  Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.

Authors:  Ali Pedram; Mahnaz Razandi; Ramesh Narayanan; James T Dalton; Timothy A McKinsey; Ellis R Levin
Journal:  Mol Biol Cell       Date:  2013-10-23       Impact factor: 4.138
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  133 in total

1.  Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells.

Authors:  Sangeeta Bhallamudi; Jennifer Connell; Christina M Pabelick; Y S Prakash; Venkatachalem Sathish
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2019-10-16       Impact factor: 5.464

Review 2.  Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation.

Authors:  S Hüser; S Guth; H G Joost; S T Soukup; J Köhrle; L Kreienbrock; P Diel; D W Lachenmeier; G Eisenbrand; G Vollmer; U Nöthlings; D Marko; A Mally; T Grune; L Lehmann; P Steinberg; S E Kulling
Journal:  Arch Toxicol       Date:  2018-08-21       Impact factor: 5.153

Review 3.  Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives.

Authors:  Matthias Barton; Edward J Filardo; Stephen J Lolait; Peter Thomas; Marcello Maggiolini; Eric R Prossnitz
Journal:  J Steroid Biochem Mol Biol       Date:  2017-03-25       Impact factor: 4.292

4.  Distribution and expression of GnRH 1, kiss receptor 2, and estradiol α and ß receptors in the anterior brain of females of Chirostoma humboldtianum.

Authors:  Beatriz Macedo-Garzón; Rosaura Loredo-Ranjel; Mónica Chávez-Maldonado; J Rafael Jiménez-Flores; Tomás E Villamar-Duque; Rodolfo Cárdenas
Journal:  Fish Physiol Biochem       Date:  2020-10-29       Impact factor: 2.794

5.  Sex Hormones and Lung Inflammation.

Authors:  Jorge Reyes-García; Luis M Montaño; Abril Carbajal-García; Yong-Xiao Wang
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

6.  Oxyresveratrol Is a Phytoestrogen Exerting Anti-inflammatory Effects Through NF-κB and Estrogen Receptor Signaling.

Authors:  Jing Wei; Jing-Rui Chen; Eva Maria Arriero Pais; Tai-Yi Wang; Lin Miao; Lan Li; Ling-Yan Li; Feng Qiu; Li-Min Hu; Xiu-Mei Gao; Guan-Wei Fan
Journal:  Inflammation       Date:  2017-08       Impact factor: 4.092

7.  Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate.

Authors:  Wan-Fu Wu; Laure Maneix; Jose Insunza; Ivan Nalvarte; Per Antonson; Juha Kere; Nancy Yiu-Lin Yu; Virpi Tohonen; Shintaro Katayama; Elisabet Einarsdottir; Kaarel Krjutskov; Yu-Bing Dai; Bo Huang; Wen Su; Margaret Warner; Jan-Åke Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205

8.  Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

Authors:  Carlotta Granchi; Margherita Lapillo; Concetta Russo Spena; Flavio Rizzolio; Tiziano Tuccinardi; Teresa A Martin; Kathryn E Carlson; John A Katzenellenbogen; Filippo Minutolo
Journal:  ChemMedChem       Date:  2016-05-02       Impact factor: 3.466

Review 9.  Risks and benefits related to alimentary exposure to xenoestrogens.

Authors:  Ilaria Paterni; Carlotta Granchi; Filippo Minutolo
Journal:  Crit Rev Food Sci Nutr       Date:  2017-11-02       Impact factor: 11.176

10.  Controlled ovarian stimulation therapy as a potential risk for the development and progression of renal cell carcinomas: A case report and literature review.

Authors:  Sotirios G Doukas; Boris Martinez; Marnie E Rosenthal; Dimitra P Vageli
Journal:  Mol Clin Oncol       Date:  2021-05-23
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