Literature DB >> 167186

Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.

Y C Cheng, B Goz, J P Neenan, D C Ward, W H Prusoff.   

Abstract

5-Amino-2,5-dideoxy-5-iodouridine, a nel thymidine analogue, is a potent inhibitor of herpes simplex virus type 1 replication. In contrast to most other nucleoside analogues which possess antiviral activity, 5-amino-2,5-dideoxy-5-iodouridine exhibits little, if any, cellular toxicity. Preliminary evidence suggests that 5-amino-2,5-dideoxy-5-iodouridine selectively inhibits viral-specific DNA synthesis.

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Year:  1975        PMID： 167186      PMCID： PMC354587     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  2 in total

1.  Acquisition of thymidine kinase activity by herpes simplex-infected mouse fibroblast cells.

Authors:  S KIT; D R DUBBS
Journal:  Biochem Biophys Res Commun       Date:  1963-04-02       Impact factor: 3.575

Review 2.  Pharmacology of viruses.

Authors:  B Goz; W H Prusoff
Journal:  Annu Rev Pharmacol       Date:  1970       Impact factor: 13.820
  2 in total
  13 in total

1.  5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.

Authors:  E De Clercq; J Descamps; D Shugar
Journal:  Antimicrob Agents Chemother       Date:  1978-03       Impact factor: 5.191

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  5,6-Dihydro-5-azathymidine: in vitro antiviral properties against human herpesviruses.

Authors:  H E Renis
Journal:  Antimicrob Agents Chemother       Date:  1978-04       Impact factor: 5.191

4.  Effects of nucleoside analogs on Epstein-Barr virus-induced transformation of human umbilical cord leukocytes and Epstein-Barr virus expression in transformed cells.

Authors:  E E Henderson; W K Long; R Ribecky
Journal:  Antimicrob Agents Chemother       Date:  1979-01       Impact factor: 5.191

5.  Effect of treatment with 5-ethyl-2'-deoxyuridine on herpes simplex virus encephalitis in normal and immunosuppressed mice.

Authors:  W B Davis; J E Oakes; J A Taylor
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

6.  In vitro antiherpesviral activity of 5-alkyl derivatives of 1-beta-D-arabinofuranosyluracil.

Authors:  H Machida; S Sakata; A Kuninaka; H Yoshino; C Nakayama; M Saneyoshi
Journal:  Antimicrob Agents Chemother       Date:  1979-08       Impact factor: 5.191

7.  Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil.

Authors:  H Machida; A Kuninaka; H Yoshino; K Ikeda; Y Mizuno
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191

8.  5'-Amino-5'-deoxythymidine: synthesis, specific phosphorylation by herpesvirus thymidine kinase, and stability to pH of the enzymically formed diphosphate derivative.

Authors:  M S Chen; G T Shiau; W H Prusoff
Journal:  Antimicrob Agents Chemother       Date:  1980-09       Impact factor: 5.191

9.  Acyclovir inhibition of Epstein-Barr virus replication.

Authors:  A K Datta; B M Colby; J E Shaw; J S Pagano
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

10.  Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.

Authors:  J F Aswell; G P Allen; A T Jamieson; D E Campbell; G A Gentry
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191
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