Literature DB >> 233730

5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.

E De Clercq, J Descamps, D Shugar.   

Abstract

In both primary rabbit kidney cells and human skin fibroblasts, 5-propyl-2'-deoxyuridine proved inhibitory to herpes simplex virus at a concentration as low as 1 micrograms/ml, whereas concentrations higher than 200 micrograms/ml were required to inhibit vaccinia virus replication or normal cell metabolism.

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Year:  1978        PMID： 233730      PMCID： PMC352280          DOI： 10.1128/AAC.13.3.545

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Recent studies on the antiviral and biochemical properties of 5-halo-5'-amino-deoxyribonucleosides.

Authors:  W H Prusoff; D C Ward; T S Lin; M S Chen; G T Shaiu; C Chai; E Lentz; R Capizzi; J Idriss; N H Ruddle; F L Black; H L Kumari; D Albert; P N Bhatt
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

2.  Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.

Authors:  T S Lin; J P Neenan; Y C Cheng; W H Prusoff
Journal:  J Med Chem       Date:  1976-04       Impact factor: 7.446

3.  Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.

Authors:  Y C Cheng; B Goz; J P Neenan; D C Ward; W H Prusoff
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

4.  Anti-herpes activity of deoxythymidine analogues: specific dependence on virus-induced deoxythymidine kinase.

Authors:  E De Clercq; E Krajewska; J Descamps; P F Torrence
Journal:  Mol Pharmacol       Date:  1977-09       Impact factor: 4.436

5.  Antiviral activity of O'-methylated derivatives of adenine arabinoside.

Authors:  E de Clercq; J Descamps; E Krajeswka; D Shugar
Journal:  Biochem Pharmacol       Date:  1977-04-15       Impact factor: 5.858

6.  [Chemotherapy of herpes infection with new 5-alkyluracildeoxyribosides].

Authors:  K K Gauri; G Malorny
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1967

7.  Cell-dependent antiherpesviral activity of 5-methylarabinosylcytosine, an intracellular ara-T donor.

Authors:  J F Aswell; G A Gentry
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

8.  Antiviral action and cellular toxicity of four thymidine analogues: 5-ethyl-,5-vinyl-, 5-propyl-, and 5-allyl-2'- deoxyuridine.

Authors:  Y C Cheng; B A Domin; R A Sharma; M Bobek
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

9.  Differential effects of 5-methylmercapto-2'-deoxyuridine on the replication of herpes simplex virus type 1 in two cell systems.

Authors:  R Hardi; R G Hughes; Y K Ho; K C Chadha; T J Bardos
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191

10.  Enzymatic basis for the selective inhibition of varicella-zoster virus by 5-halogenated analogues of deoxycytidine.

Authors:  M J Dobersen; M Jerkofsky; S Greer
Journal:  J Virol       Date:  1976-11       Impact factor: 5.103
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  8 in total

Review 1.  Specific targets for antiviral drugs.

Authors:  E De Clercq
Journal:  Biochem J       Date:  1982-07-01       Impact factor: 3.857

2.  Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.

Authors:  Federico Focher; Andrea Lossani; Annalisa Verri; Silvio Spadari; Andrew Maioli; Joseph J Gambino; George E Wright; Richard Eberle; Darla H Black; Peter Medveczky; Maria Medveczky; David Shugar
Journal:  Antimicrob Agents Chemother       Date:  2007-04-16       Impact factor: 5.191

3.  Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro.

Authors:  J P Iltis; T S Lin; W H Prusoff; F Rapp
Journal:  Antimicrob Agents Chemother       Date:  1979-07       Impact factor: 5.191

4.  (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

Authors:  E De Clercq; J Descamps; P De Somer; P J Barr; A S Jones; R T Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

5.  Thymidylate synthetase-deficient mouse FM3A mammary carcinoma cell line as a tool for studying the thymidine salvage pathway and the incorporation of thymidine analogues into host cell DNA.

Authors:  J Balzarini; E De Clercq; D Ayusawa; T Seno
Journal:  Biochem J       Date:  1984-01-01       Impact factor: 3.857

6.  In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

Authors:  E De Clercq; J Descamps; M Ogata; S Shigeta
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

7.  Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

Authors:  J Descamps; E De Clercq; P J Barr; A S Jones; R T Walker; P F Torrence; D Shugar
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

8.  Possible molecular basis for antiviral activity of certain 5-substituted deoxyuridines.

Authors:  I S Sim; J Goodchild; D M Meredith; R A Porter; R H Raper; J Viney; H J Wadsworth
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191
  8 in total

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