Literature DB >> 6250467

Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil.

H Machida, A Kuninaka, H Yoshino, K Ikeda, Y Mizuno.   

Abstract

Antiherpesviral activity of 5-vinyl-1-beta-D-arabinofuranosyluracil was as high as that of 1-beta-D-arabinofuranosylthymine, whereas the former was less inhibitory to cell growth than the latter. 5-Propenyl- and 5-butenyl-1-beta-D-arabinofuranosyluracil were less active than 5-vinyl-1-beta-D-arabinofuranosyluracil.

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Year:  1980        PMID： 6250467      PMCID： PMC283923          DOI： 10.1128/AAC.17.6.1030

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK).

Authors:  Y C Cheng
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

2.  Inhibition of herpes simplex virus replication by araT.

Authors:  G A Gentry; J F Aswell
Journal:  Virology       Date:  1975-05       Impact factor: 3.616

3.  Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.

Authors:  Y C Cheng; B Goz; J P Neenan; D C Ward; W H Prusoff
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

4.  Antiviral activity of 5-ethyl pyrimidine deoxynucleosides.

Authors:  E De Clercq; D Shugar
Journal:  Biochem Pharmacol       Date:  1975-05-15       Impact factor: 5.858

5.  Phosphorylation of arabinofuranosylthymine in non-infected and herpesvirus (TK+ and TK-)-infected cells.

Authors:  W E Müller; R K Zahn; F Arendes; D Falke
Journal:  J Gen Virol       Date:  1979-05       Impact factor: 3.891

6.  (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

Authors:  E De Clercq; J Descamps; P De Somer; P J Barr; A S Jones; R T Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

7.  Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.

Authors:  J F Aswell; G P Allen; A T Jamieson; D E Campbell; G A Gentry
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

8.  Differential effect of arabinofuranosylthymine of the replication of human herpesviruses.

Authors:  R L Miller; J P Iltis; F Rapp
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103

9.  Antiviral action and cellular toxicity of four thymidine analogues: 5-ethyl-,5-vinyl-, 5-propyl-, and 5-allyl-2'- deoxyuridine.

Authors:  Y C Cheng; B A Domin; R A Sharma; M Bobek
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

10.  Arabinosyl nucleosides. XII. Influence of arabino-furanosylthymine on growth of L5178y cells.

Authors:  W E Müller; R K Zahn; A Maidhof; R Beyer; J Arendes
Journal:  Chem Biol Interact       Date:  1978-11       Impact factor: 5.192
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  5 in total

Review 1.  Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review.

Authors:  T Kulikowski
Journal:  Pharm World Sci       Date:  1994-04-15

2.  Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus.

Authors:  H Machida; A Kuninaka; H Yoshino
Journal:  Antimicrob Agents Chemother       Date:  1982-02       Impact factor: 5.191

3.  Efficacy of 5-vinyl-1-beta-D-arabinofuranosyluracil (VaraU) against herpes simplex virus type 2 strains in cell cultures and against experimental herpes encephalitis in mice: comparison with acyclovir and foscarnet.

Authors:  J Reefschläger; P Wutzler; K D Thiel; G Herrmann
Journal:  Pharm Res       Date:  1987-06       Impact factor: 4.200

4.  Hydrogermylation of 5-ethynyluracil nucleosides: formation of 5-(2-germylvinyl)uracil and 5-(2-germylacetyl)uracil nucleosides.

Authors:  Yong Liang; Jean-Philippe Pitteloud; Stanislaw F Wnuk
Journal:  J Org Chem       Date:  2013-05-13       Impact factor: 4.354

5.  Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils.

Authors:  H Machida; S Sakata; A Kuninaka; H Yoshino
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191
  5 in total

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