| Literature DB >> 16713172 |
E M Smith1, X Wang, J Littrell, J Eckert, R Cole, A H Kissebah, M Olivier.
Abstract
The International HapMap Consortium has determined the linkage disequilibrium (LD) patterns of four major human populations. The aim of our investigation was to compare the LD patterns of the HapMap CEPH (Centre d'Etude du Polymorphisme Humain) samples with a family-based cohort of similar ancestry to determine its usefulness as a reference population for disease association studies. We examined four genomic regions on chromosomes 7q, 12p, and 14q totaling 14.3 Mb, initially identified in our linkage study of obesity and the metabolic syndrome. Near identical patterns of LD were detected in both populations. Furthermore, tagSNPs selected based on the HapMap CEPH cohort data capture over 98% of the variants at an r2 > 0.8 in the disease cohort. This confirms the usefulness of the CEPH cohort of the HapMap as a reference sample for further investigations into the genomic variation of populations of Northern European descent.Entities:
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Year: 2006 PMID： 16713172 PMCID： PMC2803324 DOI： 10.1016/j.ygeno.2006.04.004
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736