Literature DB >> 16706528

Total synthesis of (-)-mucocin.

Michael T Crimmins1, Yan Zhang, Frank A Diaz.   

Abstract

[reaction: see text] An enantioselective total synthesis of (-)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18-C34 and C7-C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments.

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Year:  2006        PMID： 16706528      PMCID： PMC2546581          DOI： 10.1021/ol060704z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  15 in total

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10.  Enantioselective total synthesis of the potent antitumor agent (-)-mucocin using a temporary silicon-tethered ring-closing metathesis cross-coupling reaction.

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