Literature DB >> 8371627

Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin.

K I Ahammadsahib1, R M Hollingworth, J P McGovren, Y H Hui, J L McLaughlin.   

Abstract

Bullatacin, a compound isolated from plants of the Annonaceae, and its analogues show in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.

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Year:  1993        PMID： 8371627     DOI： 10.1016/0024-3205(93)90547-g

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  19 in total

1.  Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.

Authors:  Jennifer M Tinsley; Eric Mertz; Pek Y Chong; Robert-André F Rarig; William R Roush
Journal:  Org Lett       Date:  2005-09-15       Impact factor: 6.005

2.  Total synthesis of (-)-mucocin.

Authors:  Michael T Crimmins; Yan Zhang; Frank A Diaz
Journal:  Org Lett       Date:  2006-05-25       Impact factor: 6.005

3.  Cardiotoxicity of acetogenins from Persea americana occurs through the mitochondrial permeability transition pore and caspase-dependent apoptosis pathways.

Authors:  Christian Silva-Platas; Noemí García; Evaristo Fernández-Sada; Daniel Dávila; Carmen Hernández-Brenes; Dariana Rodríguez; Gerardo García-Rivas
Journal:  J Bioenerg Biomembr       Date:  2012-06-26       Impact factor: 2.945

Review 4.  Mitochondrial metabolism inhibitors for cancer therapy.

Authors:  Emma E Ramsay; Philip J Hogg; Pierre J Dilda
Journal:  Pharm Res       Date:  2011-09-15       Impact factor: 4.200

5.  The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.

Authors:  Veena Coothankandaswamy; Yang Liu; Shui-Chun Mao; J Brian Morgan; Fakhri Mahdi; Mika B Jekabsons; Dale G Nagle; Yu-Dong Zhou
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

6.  Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: role of reactive oxygen species and glutathione.

Authors:  B V V Pardhasaradhi; Madhurima Reddy; A Mubarak Ali; A Leela Kumari; Ashok Khar
Journal:  J Biosci       Date:  2005-03       Impact factor: 1.826

7.  Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.

Authors:  Sandipan Datta; Fakhri Mahdi; Zulfiqar Ali; Mika B Jekabsons; Ikhlas A Khan; Dale G Nagle; Yu-Dong Zhou
Journal:  J Nat Prod       Date:  2013-12-11       Impact factor: 4.050

8.  Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).

Authors:  M Degli Esposti; A Ghelli; M Ratta; D Cortes; E Estornell
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

9.  Bullatacin--in vivo and in vitro experience in an ovarian cancer model.

Authors:  C H Holschneider; M T Johnson; R M Knox; A Rezai; W J Ryan; F J Montz
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

10.  Enantioselective total synthesis of the potent antitumor agent (-)-mucocin using a temporary silicon-tethered ring-closing metathesis cross-coupling reaction.

Authors:  P Andrew Evans; Jian Cui; Santosh J Gharpure; Alexei Polosukhin; Hai-Ren Zhang
Journal:  J Am Chem Soc       Date:  2003-12-03       Impact factor: 15.419
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