| Literature DB >> 16683772 |
P Thomas Vernier1, Matthew J Ziegler, Yinghua Sun, Wenji V Chang, Martin A Gundersen, D Peter Tieleman.
Abstract
Atomic-resolution molecular dynamics simulations of lipid bilayers containing 7% phosphatidylserine (PS) on one leaflet are consistent with experimental observations of membrane poration and PS externalization in living cells exposed to nanosecond, megavolt-per-meter electric pulses. Nanometer-diameter aqueous pores develop within nanoseconds after application of an electric field of 450 mV/nm, and electrophoretic transport of the anionic PS headgroup along the newly constructed hydrophilic pore surface commences even while pore formation is still in progress.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16683772 DOI： 10.1021/ja0588306
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419