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Literature DB >> 16679019

A terminal affair: 3'-end recognition by the human La protein.

Abstract

The La protein, an autoantigen in rheumatic disease, orchestrates several aspects of the metabolism of noncoding RNA molecules. More than 20 years ago it was shown that La primarily binds the 3' UUU-OH tails of nascent transcripts of RNA polymerase III. A recent study now reveals how the structure of the amino-terminal domain of the human La protein achieves specific 3'-end recognition.

Entities: Disease Species

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Year: 2006 PMID： 16679019 DOI： 10.1016/j.tibs.2006.04.008

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

12 in total

1. A comprehensive analysis of the La-motif protein superfamily.

Authors: Cécile Bousquet-Antonelli; Jean-Marc Deragon
Journal: RNA Date: 2009-03-19 Impact factor: 4.942

2. La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates.

Authors: Mark A Bayfield; Jyotsna Vinayak; Kyra Kerkhofs; Farnaz Mansouri-Noori
Journal: RNA Biol Date: 2019-03-18 Impact factor: 4.652

3. Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms.

Authors: Vira Bitko; Alla Musiyenko; Mark A Bayfield; Richard J Maraia; Sailen Barik
Journal: J Virol Date: 2008-06-11 Impact factor: 5.103

Review 4. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.

Authors: Richard J Maraia; Sandy Mattijssen; Isabel Cruz-Gallardo; Maria R Conte
Journal: Wiley Interdiscip Rev RNA Date: 2017-08-07 Impact factor: 9.957

Review 5. LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.

Authors: Sandy Mattijssen; Guennadi Kozlov; Bruno D Fonseca; Kalle Gehring; Richard J Maraia
Journal: RNA Biol Date: 2021-01-31 Impact factor: 4.652

6. Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.

Authors: Luigi Martino; Simon Pennell; Geoff Kelly; Tam T T Bui; Olga Kotik-Kogan; Stephen J Smerdon; Alex F Drake; Stephen Curry; Maria R Conte
Journal: Nucleic Acids Res Date: 2011-10-18 Impact factor: 16.971

A terminal affair: 3'-end recognition by the human La protein.

1. A comprehensive analysis of the La-motif protein superfamily.

2. La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates.

3. Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms.

Review 4. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.

Review 5. LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.

6. Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.

7. Precursor-product discrimination by La protein during tRNA metabolism.

8. Structural insights into mechanisms of the small RNA methyltransferase HEN1.

9. Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.

Review 10. Structural insights into RNA interference.