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Literature DB >> 16678167

Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in Arabidopsis.

Bin Yu¹, Elisabeth J Chapman, Zhiyong Yang, James C Carrington, Xuemei Chen.

Abstract

HEN1-dependent methylation of the 3'-terminal nucleotide is a crucial step in plant microRNA (miRNA) biogenesis. Here we report that several viral RNA silencing suppressors (P1/HC-Pro, p21 and p19) inhibit miRNA methylation. These suppressors have distinct effects on different miRNAs. We also show that miRNA* is methylated in vivo in a suppressor-sensitive manner, suggesting that the viral proteins interfere with miRNA/miRNA* duplexes. p19 and p21 bind both methylated and unmethylated miRNA/miRNA* duplexes in vivo. These findings suggest miRNA/miRNA* as the in vivo substrates for the HEN1 miRNA methyltransferase and raise intriguing possibilities regarding the cellular location of miRNA methylation.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 16678167 PMCID： PMC5136478 DOI： 10.1016/j.febslet.2006.04.063

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

28 in total

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Authors: Olivier Voinnet
Journal: Nat Rev Genet Date: 2005-03 Impact factor: 53.242

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Journal: Proc Natl Acad Sci U S A Date: 2005-09-12 Impact factor: 11.205

4. Probing the microRNA and small interfering RNA pathways with virus-encoded suppressors of RNA silencing.

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Journal: Plant Cell Date: 2004-04-14 Impact factor: 11.277

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Journal: Nucleic Acids Res Date: 1998-11-01 Impact factor: 16.971

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Authors: Rashid Akbergenov; Azeddine Si-Ammour; Todd Blevins; Imran Amin; Claudia Kutter; Herve Vanderschuren; Peng Zhang; Wilhelm Gruissem; Frederick Meins; Thomas Hohn; Mikhail M Pooggin
Journal: Nucleic Acids Res Date: 2006-01-18 Impact factor: 16.971

7. CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana.

Authors: Wonkeun Park; Junjie Li; Rentao Song; Joachim Messing; Xuemei Chen
Journal: Curr Biol Date: 2002-09-03 Impact factor: 10.834

8. Methylation as a crucial step in plant microRNA biogenesis.

Authors: Bin Yu; Zhiyong Yang; Junjie Li; Svetlana Minakhina; Maocheng Yang; Richard W Padgett; Ruth Steward; Xuemei Chen
Journal: Science Date: 2005-02-11 Impact factor: 47.728

9. Genetic and functional diversification of small RNA pathways in plants.

Authors: Zhixin Xie; Lisa K Johansen; Adam M Gustafson; Kristin D Kasschau; Andrew D Lellis; Daniel Zilberman; Steven E Jacobsen; James C Carrington
Journal: PLoS Biol Date: 2004-02-24 Impact factor: 8.029

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Authors: Xiu-Jie Wang; José L Reyes; Nam-Hai Chua; Terry Gaasterland
Journal: Genome Biol Date: 2004-08-31 Impact factor: 13.583

40 in total

Review 1. Regulation of small RNA stability: methylation and beyond.

Authors: Lijuan Ji; Xuemei Chen
Journal: Cell Res Date: 2012-03-13 Impact factor: 25.617

2. Modification of small RNAs associated with suppression of RNA silencing by tobamovirus replicase protein.

Authors: Hannes Vogler; Rashid Akbergenov; Padubidri V Shivaprasad; Vy Dang; Monika Fasler; Myoung-Ok Kwon; Saule Zhanybekova; Thomas Hohn; Manfred Heinlein
Journal: J Virol Date: 2007-07-18 Impact factor: 5.103

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Authors: Xuemei Chen
Journal: Curr Top Microbiol Immunol Date: 2008 Impact factor: 4.291

Review 4. Antiviral immunity directed by small RNAs.

Authors: Shou-Wei Ding; Olivier Voinnet
Journal: Cell Date: 2007-08-10 Impact factor: 41.582

5. Quantitative evaluation of six different viral suppressors of silencing using image analysis of transient GFP expression.

Authors: Taniya Dhillon; Joseph M Chiera; John A Lindbo; John J Finer
Journal: Plant Cell Rep Date: 2009-02-06 Impact factor: 4.570

6. Quantification and extension of transient GFP expression by the co-introduction of a suppressor of silencing.

Authors: Joseph M Chiera; John A Lindbo; John J Finer
Journal: Transgenic Res Date: 2008-06-12 Impact factor: 2.788

7. From hypo- to hypersuppression: effect of amino acid substitutions on the RNA-silencing suppressor activity of the Tobacco etch potyvirus HC-Pro.

Authors: Clara Torres-Barceló; Susana Martín; José-Antonio Daròs; Santiago F Elena
Journal: Genetics Date: 2008-09-09 Impact factor: 4.562