Literature DB >> 16672626

Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.

Veerabadran Dheenadhayalan1, Giovanni Delogu, Maurizio Sanguinetti, Giovanni Fadda, Michael J Brennan.   

Abstract

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

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Year:  2006        PMID： 16672626      PMCID： PMC1482869          DOI： 10.1128/JB.188.10.3721-3725.2006

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

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Authors:  Mark A Fisher; Bonnie B Plikaytis; Thomas M Shinnick
Journal:  J Bacteriol       Date:  2002-07       Impact factor: 3.490

2.  Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival.

Authors:  Veerabadran Dheenadhayalan; Giovanni Delogu; Michael J Brennan
Journal:  Microbes Infect       Date:  2005-09-12       Impact factor: 2.700

3.  The PE-PGRS glycine-rich proteins of Mycobacterium tuberculosis: a new family of fibronectin-binding proteins?

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Journal:  Microbiology       Date:  1999-12       Impact factor: 2.777

4.  Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis.

Authors:  G Delogu; M J Brennan
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

5.  Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.

Authors:  Joanna C Betts; Pauline T Lukey; Linda C Robb; Ruth A McAdam; Ken Duncan
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

6.  A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR.

Authors:  J Meijerink; C Mandigers; L van de Locht; E Tönnissen; F Goodsaid; J Raemaekers
Journal:  J Mol Diagn       Date:  2001-05       Impact factor: 5.568

7.  Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens?

Authors:  Sayera Banu; Nadine Honoré; Brigitte Saint-Joanis; Dana Philpott; Marie-Christine Prévost; Stewart T Cole
Journal:  Mol Microbiol       Date:  2002-04       Impact factor: 3.501

8.  Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells.

Authors:  M J Brennan; G Delogu; Y Chen; S Bardarov; J Kriakov; M Alavi; W R Jacobs
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

9.  Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.

Authors:  R D Fleischmann; D Alland; J A Eisen; L Carpenter; O White; J Peterson; R DeBoy; R Dodson; M Gwinn; D Haft; E Hickey; J F Kolonay; W C Nelson; L A Umayam; M Ermolaeva; S L Salzberg; A Delcher; T Utterback; J Weidman; H Khouri; J Gill; A Mikula; W Bishai; W R Jacobs; J C Venter; C M Fraser
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

10.  ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.

Authors:  G Marcela Rodriguez; Martin I Voskuil; Benjamin Gold; Gary K Schoolnik; Issar Smith
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441
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  25 in total

1.  In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis.

Authors:  Edith E Machowski; Samantha Barichievy; Burkhard Springer; Steven I Durbach; Valerie Mizrahi
Journal:  J Bacteriol       Date:  2006-12-15       Impact factor: 3.490

2.  Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis.

Authors:  Sahadevan Raman; Xiaoling Puyang; Tan-Yun Cheng; David C Young; D Branch Moody; Robert N Husson
Journal:  J Bacteriol       Date:  2006-10-06       Impact factor: 3.490

3.  Identification of factors for tuberculosis transmission via an integrated multidisciplinary approach.

Authors:  Sarah Talarico; Kashef Ijaz; Xinyu Zhang; Leonard N Mukasa; Lixin Zhang; Carl F Marrs; M Donald Cave; Joseph H Bates; Zhenhua Yang
Journal:  Tuberculosis (Edinb)       Date:  2011-03-01       Impact factor: 3.131

4.  Expression of PE_PGRS 62 protein in Mycobacterium smegmatis decrease mRNA expression of proinflammatory cytokines IL-1beta, IL-6 in macrophages.

Authors:  Ying Huang; Yang Wang; Yu Bai; Zhi Gang Wang; Lifeng Yang; Deming Zhao
Journal:  Mol Cell Biochem       Date:  2010-03-11       Impact factor: 3.396

5.  Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages.

Authors:  Samradhni S Jha; Lia Danelishvili; Dirk Wagner; Jörg Maser; Yong-jun Li; Ivana Moric; Steven Vogt; Yoshitaka Yamazaki; Barry Lai; Luiz E Bermudez
Journal:  BMC Microbiol       Date:  2010-04-01       Impact factor: 3.605

6.  Global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection.

Authors:  Patricia Fontán; Virginie Aris; Saleena Ghanny; Patricia Soteropoulos; Issar Smith
Journal:  Infect Immun       Date:  2007-12-10       Impact factor: 3.441

7.  The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA.

Authors:  Ling Zhu; Sangita Phadtare; Hirofumi Nariya; Ming Ouyang; Robert N Husson; Masayori Inouye
Journal:  Mol Microbiol       Date:  2008-06-28       Impact factor: 3.501

8.  The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence.

Authors:  Rachael M Goldstone; Sunali D Goonesekera; Barry R Bloom; Samantha L Sampson
Journal:  Infect Immun       Date:  2009-08-03       Impact factor: 3.441

9.  Mycobacterium tuberculosis PE_PGRS16 and PE_PGRS26 genetic polymorphism among clinical isolates.

Authors:  Sarah Talarico; Lixin Zhang; Carl F Marrs; Betsy Foxman; M Donald Cave; Michael J Brennan; Zhenhua Yang
Journal:  Tuberculosis (Edinb)       Date:  2008-03-04       Impact factor: 3.131

Review 10.  Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis.

Authors:  Simon J Waddell; Philip D Butcher
Journal:  Curr Mol Med       Date:  2007-05       Impact factor: 2.222
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