Literature DB >> 12081975

Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes.

Mark A Fisher1, Bonnie B Plikaytis, Thomas M Shinnick.   

Abstract

We used microarrays and real-time reverse transcription-PCR to analyze the global transcriptional response of Mycobacterium tuberculosis to low pH in vitro, which may mimic an environmental signal encountered by phagocytosed mycobacteria. Eighty-one genes were differentially expressed >1.5-fold, including many involved in fatty acid metabolism. The most highly induced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.

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Year:  2002        PMID： 12081975      PMCID： PMC135184          DOI： 10.1128/JB.184.14.4025-4032.2002

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  53 in total

1.  Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003.

Authors:  L Du; B Shen
Journal:  Chem Biol       Date:  1999-08

2.  DNA arrays for analysis of gene expression.

Authors:  M B Eisen; P O Brown
Journal:  Methods Enzymol       Date:  1999       Impact factor: 1.600

3.  Real time quantitative PCR.

Authors:  C A Heid; J Stevens; K J Livak; P M Williams
Journal:  Genome Res       Date:  1996-10       Impact factor: 9.043

4.  Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS).

Authors:  J E Graham; J E Clark-Curtiss
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

5.  Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.

Authors:  I E Holzbaur; R C Harris; M Bycroft; J Cortes; C Bisang; J Staunton; B A Rudd; P F Leadlay
Journal:  Chem Biol       Date:  1999-04

6.  Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon.

Authors:  A R Horswill; J C Escalante-Semerena
Journal:  J Bacteriol       Date:  1997-02       Impact factor: 3.490

7.  Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.

Authors:  J D McKinney; K Höner zu Bentrup; E J Muñoz-Elías; A Miczak; B Chen; W T Chan; D Swenson; J C Sacchettini; W R Jacobs; D G Russell
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

8.  Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase.

Authors:  S Sturgill-Koszycki; P H Schlesinger; P Chakraborty; P L Haddix; H L Collins; A K Fok; R D Allen; S L Gluck; J Heuser; D G Russell
Journal:  Science       Date:  1994-02-04       Impact factor: 47.728

9.  Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosome-lysosome interaction.

Authors:  Y K Oh; R M Straubinger
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

10.  Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Authors:  S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962
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  147 in total

1.  Molecular modeling studies of Fatty acyl-CoA synthetase (FadD13) from Mycobacterium tuberculosis--a potential target for the development of antitubercular drugs.

Authors:  Nidhi Jatana; Sarvesh Jangid; Garima Khare; Anil K Tyagi; Narayanan Latha
Journal:  J Mol Model       Date:  2010-05-08       Impact factor: 1.810

Review 2.  Surviving the acid test: responses of gram-positive bacteria to low pH.

Authors:  Paul D Cotter; Colin Hill
Journal:  Microbiol Mol Biol Rev       Date:  2003-09       Impact factor: 11.056

3.  Systems biology approaches to understanding mycobacterial survival mechanisms.

Authors:  Helena I M Boshoff; Desmond S Lun
Journal:  Drug Discov Today Dis Mech       Date:  2010

4.  Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress.

Authors:  Tatiana D Sirakova; Vinod S Dubey; Chirajyoti Deb; Jaiyanth Daniel; Tatiana A Korotkova; Bassam Abomoelak; Pappachan E Kolattukudy
Journal:  Microbiology (Reading)       Date:  2006-09       Impact factor: 2.777

5.  Role of GlnR in acid-mediated repression of genes encoding proteins involved in glutamine and glutamate metabolism in Streptococcus mutans.

Authors:  Pei-Min Chen; Yi-Ywan M Chen; Sung-Liang Yu; Singh Sher; Chern-Hsiung Lai; Jean-San Chia
Journal:  Appl Environ Microbiol       Date:  2010-02-19       Impact factor: 4.792

6.  Identification of genes regulated by changing salinity in the deep-sea bacterium Shewanella sp. WP3 using RNA arbitrarily primed PCR.

Authors:  Shengkang Li; Xiang Xiao; Jinyuan Li; Jinxian Luo; Fengping Wang
Journal:  Extremophiles       Date:  2005-08-24       Impact factor: 2.395

7.  In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis.

Authors:  Edith E Machowski; Samantha Barichievy; Burkhard Springer; Steven I Durbach; Valerie Mizrahi
Journal:  J Bacteriol       Date:  2006-12-15       Impact factor: 3.490

8.  Lipidomic analyses of Mycobacterium tuberculosis based on accurate mass measurements and the novel "Mtb LipidDB".

Authors:  Mark J Sartain; Donald L Dick; Christopher D Rithner; Dean C Crick; John T Belisle
Journal:  J Lipid Res       Date:  2011-02-01       Impact factor: 5.922

9.  Individual Mycobacterium tuberculosis resuscitation-promoting factor homologues are dispensable for growth in vitro and in vivo.

Authors:  JoAnn M Tufariello; William R Jacobs; John Chan
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

10.  Enhanced functional and structural domain assignments using remote similarity detection procedures for proteins encoded in the genome of Mycobacterium tuberculosis H37Rv.

Authors:  Seema Namboori; Natasha Mhatre; Sentivel Sujatha; Narayanaswamy Srinivasan; Shashi Bhushan Pandit
Journal:  J Biosci       Date:  2004-09       Impact factor: 1.826
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