Literature DB >> 17172340

In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis.

Edith E Machowski1, Samantha Barichievy, Burkhard Springer, Steven I Durbach, Valerie Mizrahi.   

Abstract

An assay modeled on a known polymorphism in the PE_PGRS9 gene of Mycobacterium tuberculosis was designed to assess the mutability of a sequence containing interspersed PGRS repeats. Application of the assay in Mycobacterium smegmatis revealed sequence plasticity: in addition to recapitulating the mutation on which it was based, other mutations likely mediated by replication slippage between PGRS repeats were detected. However, the mutation rates argued against marked hypermutability of such sequences in mycobacteria.

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Year:  2006        PMID： 17172340      PMCID： PMC1855714          DOI： 10.1128/JB.01647-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  32 in total

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4.  PE_PGRS proteins are differentially expressed by Mycobacterium tuberculosis in host tissues.

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Journal:  Microbes Infect       Date:  2006-06-05       Impact factor: 2.700

5.  The distribution of the numbers of mutants in bacterial populations.

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Authors:  Joanna C Betts; Pauline T Lukey; Linda C Robb; Ruth A McAdam; Ken Duncan
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

7.  Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens?

Authors:  Sayera Banu; Nadine Honoré; Brigitte Saint-Joanis; Dana Philpott; Marie-Christine Prévost; Stewart T Cole
Journal:  Mol Microbiol       Date:  2002-04       Impact factor: 3.501

8.  Lack of mismatch correction facilitates genome evolution in mycobacteria.

Authors:  Burkhard Springer; Peter Sander; Ludwig Sedlacek; Wolf-Dietrich Hardt; Valerie Mizrahi; Primo Schär; Erik C Böttger
Journal:  Mol Microbiol       Date:  2004-09       Impact factor: 3.501

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Authors:  S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
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Authors:  R D Fleischmann; D Alland; J A Eisen; L Carpenter; O White; J Peterson; R DeBoy; R Dodson; M Gwinn; D Haft; E Hickey; J F Kolonay; W C Nelson; L A Umayam; M Ermolaeva; S L Salzberg; A Delcher; T Utterback; J Weidman; H Khouri; J Gill; A Mikula; W Bishai; W R Jacobs; J C Venter; C M Fraser
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490
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Authors:  Yi Wang; Yuanxia Huang; Chaolun Xue; Yang He; Zheng-Guo He
Journal:  J Biol Chem       Date:  2011-07-19       Impact factor: 5.157

2.  Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis.

Authors:  Bavesh D Kana; Garth L Abrahams; Nackmoon Sung; Digby F Warner; Bhavna G Gordhan; Edith E Machowski; Liana Tsenova; James C Sacchettini; Neil G Stoker; Gilla Kaplan; Valerie Mizrahi
Journal:  J Bacteriol       Date:  2010-02-05       Impact factor: 3.490

3.  PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6.

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Journal:  Front Immunol       Date:  2022-04-28       Impact factor: 8.786

4.  Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria.

Authors:  Mohube B Mowa; Digby F Warner; Gilla Kaplan; Bavesh D Kana; Valerie Mizrahi
Journal:  J Bacteriol       Date:  2008-11-21       Impact factor: 3.490

5.  Spontaneous emergence of multiple drug resistance in tuberculosis before and during therapy.

Authors:  Caroline Colijn; Ted Cohen; Ayalvadi Ganesh; Megan Murray
Journal:  PLoS One       Date:  2011-03-30       Impact factor: 3.240

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Authors:  Min Yang; Chunhui Gao; Tao Cui; Jingning An; Zheng-Guo He
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7.  DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis.

Authors:  Melissa D Chengalroyen; Mandy K Mason; Alessandro Borsellini; Raffaella Tassoni; Garth L Abrahams; Sasha Lynch; Yong-Mo Ahn; Jon Ambler; Katherine Young; Brendan M Crowley; David B Olsen; Digby F Warner; Clifton E Barry Iii; Helena I M Boshoff; Meindert H Lamers; Valerie Mizrahi
Journal:  ACS Infect Dis       Date:  2022-02-10       Impact factor: 5.084

8.  Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.

Authors:  Christopher R E McEvoy; Paul D van Helden; Robin M Warren; Nicolaas C Gey van Pittius
Journal:  BMC Evol Biol       Date:  2009-09-21       Impact factor: 3.260

9.  Evolution of smooth tubercle Bacilli PE and PE_PGRS genes: evidence for a prominent role of recombination and imprint of positive selection.

Authors:  Amine Namouchi; Anis Karboul; Michel Fabre; Maria Cristina Gutierrez; Helmi Mardassi
Journal:  PLoS One       Date:  2013-05-21       Impact factor: 3.240

10.  The role of glutamine oxoglutarate aminotransferase and glutamate dehydrogenase in nitrogen metabolism in Mycobacterium bovis BCG.

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  10 in total

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