Literature DB >> 16665675

Inhibition of na/h antiport activity in sugar beet tonoplast by analogs of amiloride.

E Blumwald1, E J Cragoe, R J Poole.   

Abstract

The effects of amiloride and a series of amiloride analogs have been tested on the Na(+)/H(+) antiport activity in intact vacuoles and tonoplast vesicles isolated from sugar beet cell suspension cultures. There is a competitive interaction between amiloride analogs and sodium. Substitution of one or both H-atoms of the 5-amino group of amiloride (apparent K(i) about 150 micromolar) resulted in a 3- to 200-fold increase in inhibitory potency of the antiport activity.

Entities:  

Year:  1987        PMID： 16665675      PMCID： PMC1054197          DOI： 10.1104/pp.85.1.30

Source DB:  PubMed          Journal:  Plant Physiol        ISSN： 0032-0889            Impact factor:   8.340


  12 in total

1.  Assessment of cytoplasmic contaminations in isolated vacuole preparations.

Authors:  A Admon; B Jacoby
Journal:  Plant Physiol       Date:  1980-01       Impact factor: 8.340

2.  Na+/H+ exchanger activity in the pig kidney epithelial cell line, LLC-PK1: inhibition by amiloride and its derivatives.

Authors:  J G Haggerty; E J Cragoe; C W Slayman; E A Adelberg
Journal:  Biochem Biophys Res Commun       Date:  1985-03-29       Impact factor: 3.575

3.  Kinetics of Ca/H Antiport in Isolated Tonoplast Vesicles from Storage Tissue of Beta vulgaris L.

Authors:  E Blumwald; R J Poole
Journal:  Plant Physiol       Date:  1986-03       Impact factor: 8.340

4.  Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides.

Authors:  E J Cragoe; O W Woltersdorf; J B Bicking; S F Kwong; J H Jones
Journal:  J Med Chem       Date:  1967-01       Impact factor: 7.446

5.  Nitrate storage and retrieval in Beta vulgaris: Effects of nitrate and chloride on proton gradients in tonoplast vesicles.

Authors:  E Blumwald; R J Poole
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

6.  Sugar transport into protoplasts isolated from developing soybean cotyledons : I. Protoplast isolation and general characteristics of sugar transport.

Authors:  W Lin; M R Schmitt; W D Hitz; R T Giaquinta
Journal:  Plant Physiol       Date:  1984-08       Impact factor: 8.340

7.  Salt tolerance in suspension cultures of sugar beet : induction of na/h antiport activity at the tonoplast by growth in salt.

Authors:  E Blumwald; R J Poole
Journal:  Plant Physiol       Date:  1987-04       Impact factor: 8.340

8.  Na/H Antiport in Isolated Tonoplast Vesicles from Storage Tissue of Beta vulgaris.

Authors:  E Blumwald; R J Poole
Journal:  Plant Physiol       Date:  1985-05       Impact factor: 8.340

9.  Structure-activity relationships of amiloride and certain of its analogues in relation to the blockade of the Na+/H+ exchange system.

Authors:  P Vigne; C Frelin; E J Cragoe; M Lazdunski
Journal:  Mol Pharmacol       Date:  1984-01       Impact factor: 4.436

10.  Characterization of potent Na+/H+ exchange inhibitors from the amiloride series in A431 cells.

Authors:  Y Zhuang; E J Cragoe; T Shaikewitz; L Glaser; D Cassel
Journal:  Biochemistry       Date:  1984-09-11       Impact factor: 3.162
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  16 in total

1.  Regulation of Vacuolar pH of Plant Cells: II. A P NMR Study of the Modifications of Vacuolar pH in Isolated Vacuoles Induced by Proton Pumping and Cation/H Exchanges.

Authors:  J Guern; Y Mathieu; A Kurkdjian; P Manigault; J Manigault; B Gillet; J C Beloeil; J Y Lallemand
Journal:  Plant Physiol       Date:  1989-01       Impact factor: 8.340

2.  Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei.

Authors:  A E Vercesi; R Docampo
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

3.  Na+/H+ antiporter from Synechocystis species PCC 6803, homologous to SOS1, contains an aspartic residue and long C-terminal tail important for the carrier activity.

Authors:  A Hamada; T Hibino; T Nakamura; T Takabe
Journal:  Plant Physiol       Date:  2001-01       Impact factor: 8.340

4.  Identification of a 170-kDa protein associated with the vacuolar Na+/H+ antiport of Beta vulgaris.

Authors:  B J Barkla; E Blumwald
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

5.  Halotolerant cyanobacterium Aphanothece halophytica contains NapA-type Na+/H+ antiporters with novel ion specificity that are involved in salt tolerance at alkaline pH.

Authors:  Nuchanat Wutipraditkul; Rungaroon Waditee; Aran Incharoensakdi; Takashi Hibino; Yoshito Tanaka; Tatsunosuke Nakamura; Masamitsu Shikata; Tetsuko Takabe; Teruhiro Takabe
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

Review 6.  Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells.

Authors:  E Padan; S Schuldiner
Journal:  J Bioenerg Biomembr       Date:  1993-12       Impact factor: 2.945

7.  Photolabeling of tonoplast from sugar beet cell suspensions by [h]5-(N-methyl-N-isobutyl)-amiloride, an inhibitor of the vacuolar na/h antiport.

Authors:  B J Barkla; J H Charuk; E J Cragoe; E Blumwald
Journal:  Plant Physiol       Date:  1990-07       Impact factor: 8.340

8.  An in Vivo Nuclear Magnetic Resonance Investigation of Ion Transport in Maize (Zea mays) and Spartina anglica Roots during Exposure to High Salt Concentrations.

Authors:  C. M. Spickett; N. Smirnoff; R. G. Ratcliffe
Journal:  Plant Physiol       Date:  1993-06       Impact factor: 8.340

9.  Plasma Membrane Na+ Transport in a Salt-Tolerant Charophyte (Isotopic Fluxes, Electrophysiology, and Thermodynamics in Plants Adapted to Saltwater and Freshwater).

Authors:  E. A. Kiegle; M. A. Bisson
Journal:  Plant Physiol       Date:  1996-08       Impact factor: 8.340

10.  The sugar beet gene encoding the sodium/proton exchanger 1 (BvNHX1) is regulated by a MYB transcription factor.

Authors:  Guy Adler; Eduardo Blumwald; Dudy Bar-Zvi
Journal:  Planta       Date:  2010-06       Impact factor: 4.116
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