Literature DB >> 8144493

Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells.

E Padan1, S Schuldiner.   

Abstract

Na+/H+ antiporters are universal devices involved in the Na+ and H+ circulation of both eukaryotes and prokaryotes, thus playing an essential role in the pH and Na+ homeostasis of cells. This review focuses on the major impact of the application of molecular biology tools in the study of the antiporters. These tools permit the verification of the role of the antiporters and provide insights into their unique biology. A novel signal transduction to Na+ involving nhaR, a positive regulator, controls the expression of nhaA in E. coli. A "pH sensor" regulates the activity of Na+/H+ antiporters, both in eukaryotes and prokaryotes. A most intricate signal transduction to pH involving phosphorylation steps controls the activity of nhel in higher mammals. The identification of Histidine 226 in the "pH sensor" of NhaA is a step forward towards the understanding of the pH regulation of these proteins.

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Year:  1993        PMID： 8144493     DOI： 10.1007/bf00770252

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  156 in total

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Authors:  T A Krulwich; A A Guffanti
Journal:  J Bioenerg Biomembr       Date:  1992-12       Impact factor: 2.945

2.  Cooperative regulation of the Na+/H(+)-antiporter in Halobacterium halobium by delta pH and delta phi.

Authors:  N Murakami; T Konishi
Journal:  Arch Biochem Biophys       Date:  1990-08-15       Impact factor: 4.013

Review 3.  Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human: Traffic ATPases.

Authors:  G F Ames; C S Mimura; V Shyamala
Journal:  FEMS Microbiol Rev       Date:  1990-08       Impact factor: 16.408

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Authors:  C Sardet; A Franchi; J Pouysségur
Journal:  Cell       Date:  1989-01-27       Impact factor: 41.582

5.  A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

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Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

6.  Bioenergetics of alkalophilic bacteria.

Authors:  T A Krulwich
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

7.  Purification of a reconstitutively active K+/H+ antiporter from rat liver mitochondria.

Authors:  X Q Li; M G Hegazy; F Mahdi; P Jezek; R D Lane; K D Garlid
Journal:  J Biol Chem       Date:  1990-09-05       Impact factor: 5.157

8.  Expression cloning in yeast of a cDNA encoding a broad specificity amino acid permease from Arabidopsis thaliana.

Authors:  W B Frommer; S Hummel; J W Riesmeier
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

9.  Homologous metalloregulatory proteins from both gram-positive and gram-negative bacteria control transcription of mercury resistance operons.

Authors:  J D Helmann; Y Wang; I Mahler; C T Walsh
Journal:  J Bacteriol       Date:  1989-01       Impact factor: 3.490

10.  A proton-translocating ATPase regulates pH of the bacterial cytoplasm.

Authors:  H Kobayashi
Journal:  J Biol Chem       Date:  1985-01-10       Impact factor: 5.157
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  19 in total

Review 1.  The Na+-translocating NADH:quinone oxidoreductase (NDH I) from Klebsiella pneumoniae and Escherichia coli: implications for the mechanism of redox-driven cation translocation by complex I.

Authors:  J Steuber
Journal:  J Bioenerg Biomembr       Date:  2001-06       Impact factor: 2.945

Review 2.  Alkaline pH homeostasis in bacteria: new insights.

Authors:  Etana Padan; Eitan Bibi; Masahiro Ito; Terry A Krulwich
Journal:  Biochim Biophys Acta       Date:  2005-09-26

Review 3.  Linkage map of Escherichia coli K-12, edition 10: the traditional map.

Authors:  M K Berlyn
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

4.  Na+-induced transcription of nhaA, which encodes an Na+/H+ antiporter in Escherichia coli, is positively regulated by nhaR and affected by hns.

Authors:  N Dover; C F Higgins; O Carmel; A Rimon; E Pinner; E Padan
Journal:  J Bacteriol       Date:  1996-11       Impact factor: 3.490

Review 5.  Architecture of bacterial respiratory chains.

Authors:  Ville R I Kaila; Mårten Wikström
Journal:  Nat Rev Microbiol       Date:  2021-01-12       Impact factor: 60.633

6.  Role of the nhaC-encoded Na+/H+ antiporter of alkaliphilic Bacillus firmus OF4.

Authors:  M Ito; A A Guffanti; J Zemsky; D M Ivey; T A Krulwich
Journal:  J Bacteriol       Date:  1997-06       Impact factor: 3.490

7.  Transcription of nhaA, the main Na(+)/H(+) antiporter of Escherichia coli, is regulated by Na(+) and growth phase.

Authors:  N Dover; E Padan
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

8.  Revealing the salinity adaptation mechanism in halotolerant bacterium Egicoccus halophilus EGI 80432T by physiological analysis and comparative transcriptomics.

Authors:  Dai-Di Chen; Bao-Zhu Fang; Ahmad Manzoor; Yong-Hong Liu; Li Li; Osama Abdalla Abdelshafy Mohamad; Wen-Sheng Shu; Wen-Jun Li
Journal:  Appl Microbiol Biotechnol       Date:  2021-02-24       Impact factor: 4.813

9.  Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence.

Authors:  Michal Maes; Abraham Rimon; Lena Kozachkov-Magrisso; Assaf Friedler; Etana Padan
Journal:  J Biol Chem       Date:  2012-08-22       Impact factor: 5.157

10.  The Na+-translocating ATPase in the plasma membrane of the marine microalga Tetraselmis viridis catalyzes Na+/H+ exchange.

Authors:  Yurii V Balnokin; Larissa G Popova; Lyudmila Y Pagis; Igor M Andreev
Journal:  Planta       Date:  2004-03-03       Impact factor: 4.116
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