Literature DB >> 16647256

Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors.

Jon Bondebjerg1, Henrik Fuglsang, Kirsten Rosendal Valeur, John Pedersen, Lars Naerum.   

Abstract

Using a dipeptide nitrile scaffold we have identified a potent and selective inhibitor of human dipeptidyl peptidase I.

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Year:  2006        PMID： 16647256     DOI： 10.1016/j.bmcl.2006.01.102

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Discovery of novel cyanamide-based inhibitors of cathepsin C.

Authors:  Dramane Lainé; Michael Palovich; Brent McCleland; Emilie Petitjean; Isabelle Delhom; Haibo Xie; Jianghe Deng; Guoliang Lin; Roderick Davis; Anais Jolit; Neysa Nevins; Baoguang Zhao; Jim Villa; Jessica Schneck; Patrick McDevitt; Robert Midgett; Casey Kmett; Sandra Umbrecht; Brian Peck; Alicia Bacon Davis; David Bettoun
Journal:  ACS Med Chem Lett       Date:  2010-11-10       Impact factor: 4.345

2.  Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1.

Authors:  Flora Wang; Priscilla Krai; Edgar Deu; Brittney Bibb; Conni Lauritzen; John Pedersen; Matthew Bogyo; Michael Klemba
Journal:  Mol Biochem Parasitol       Date:  2010-09-15       Impact factor: 1.759

3.  Identification, immunolocalization, and characterization analyses of an exopeptidase of papain superfamily, (cathepsin C) from Clonorchis sinensis.

Authors:  Pei Liang; Lei He; Yanquan Xu; Xueqing Chen; Yan Huang; Mengyu Ren; Chi Liang; Xuerong Li; Jin Xu; Gang Lu; Xinbing Yu
Journal:  Parasitol Res       Date:  2014-08-21       Impact factor: 2.289

4.  Strecker-Derived Methodology for Library Synthesis of N-Acylated α-Aminonitriles.

Authors:  Pedro Gonçalves; Anke Peeraer; Yves Adriaenssens; Lara Zonnekein; Philippe Franck; Bert U W Maes; Koen Augustyns; Pieter Van Der Veken
Journal:  ACS Omega       Date:  2021-01-07

Review 5.  Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

Authors:  Brice Korkmaz; Adam Lesner; Sylvain Marchand-Adam; Celia Moss; Dieter E Jenne
Journal:  J Med Chem       Date:  2020-08-07       Impact factor: 7.446
  5 in total

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