Literature DB >> 24900293

Discovery of novel cyanamide-based inhibitors of cathepsin C.

Dramane Lainé1, Michael Palovich1, Brent McCleland1, Emilie Petitjean1, Isabelle Delhom1, Haibo Xie1, Jianghe Deng1, Guoliang Lin1, Roderick Davis1, Anais Jolit1, Neysa Nevins1, Baoguang Zhao1, Jim Villa1, Jessica Schneck1, Patrick McDevitt1, Robert Midgett1, Casey Kmett1, Sandra Umbrecht1, Brian Peck1, Alicia Bacon Davis1, David Bettoun1.   

Abstract

The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease cathepsin C is detailed. Optimization of the template with regard to plasma stability led to the identification of compound 17, a potent cathepsin C inhibitor with excellent selectivity over other cathepsins and potent in vivo activity in a cigarette smoke mouse model.

Entities:  

Keywords:  Cathepsin C inhibitors; cigarette smoke; cyanamides; potent; selective

Year:  2010        PMID： 24900293      PMCID： PMC4018094          DOI： 10.1021/ml100212k

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  35 in total

1.  Purification and characterization of dipeptidyl peptidase I from human spleen.

Authors:  M J McGuire; P E Lipsky; D L Thiele
Journal:  Arch Biochem Biophys       Date:  1992-06       Impact factor: 4.013

2.  New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones.

Authors:  J K McDonald; B B Zeitman; T J Reilly; S Ellis
Journal:  J Biol Chem       Date:  1969-05-25       Impact factor: 5.157

3.  Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.

Authors:  D Turk; V Janjić; I Stern; M Podobnik; D Lamba; S W Dahl; C Lauritzen; J Pedersen; V Turk; B Turk
Journal:  EMBO J       Date:  2001-12-03       Impact factor: 11.598

4.  A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8+ T cell cytotoxic effector function.

Authors:  D L Thiele; M J McGuire; P E Lipsky
Journal:  J Immunol       Date:  1997-06-01       Impact factor: 5.422

5.  Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo.

Authors:  C T Pham; T J Ley
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

6.  L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.

Authors:  A J Barrett; A A Kembhavi; M A Brown; H Kirschke; C G Knight; M Tamai; K Hanada
Journal:  Biochem J       Date:  1982-01-01       Impact factor: 3.857

7.  Mast cell dipeptidyl peptidase I mediates survival from sepsis.

Authors:  Jon Mallen-St Clair; Christine T N Pham; S Armando Villalta; George H Caughey; Paul J Wolters
Journal:  J Clin Invest       Date:  2004-02       Impact factor: 14.808

8.  Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.

Authors:  Nathalie Méthot; Joel Rubin; Daniel Guay; Christian Beaulieu; Diane Ethier; T Jagadeeswar Reddy; Denis Riendeau; M David Percival
Journal:  J Biol Chem       Date:  2007-05-29       Impact factor: 5.157

9.  Selective inhibition of dipeptidyl peptidase I, not caspases, prevents the partial processing of procaspase-3 in CD3-activated human CD8(+) T lymphocytes.

Authors:  Nicolas Bidère; Marie Briet; Antoine Dürrbach; Céline Dumont; Jérôme Feldmann; Bernard Charpentier; Geneviève de Saint-Basile; Anna Senik
Journal:  J Biol Chem       Date:  2002-06-21       Impact factor: 5.157

Review 10.  Role of neutrophils in mucus hypersecretion in COPD and implications for therapy.

Authors:  Suil Kim; Jay A Nadel
Journal:  Treat Respir Med       Date:  2004
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  9 in total

1.  DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.

Authors:  Helena Käck; Kevin Doyle; Samantha J Hughes; Michael S Bodnarchuk; Hans Lönn; Amanda Van De Poël; Nicholas Palmer
Journal:  ACS Med Chem Lett       Date:  2019-07-15       Impact factor: 4.345

2.  USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

Authors:  Emma V Rusilowicz-Jones; Jane Jardine; Andreas Kallinos; Adan Pinto-Fernandez; Franziska Guenther; Mariacarmela Giurrandino; Francesco G Barone; Katy McCarron; Christopher J Burke; Alejandro Murad; Aitor Martinez; Elena Marcassa; Malte Gersch; Alexandre J Buckmelter; Katherine J Kayser-Bricker; Frederic Lamoliatte; Akshada Gajbhiye; Simon Davis; Hannah C Scott; Emma Murphy; Katherine England; Heather Mortiboys; David Komander; Matthias Trost; Benedikt M Kessler; Stephanos Ioannidis; Michael K Ahlijanian; Sylvie Urbé; Michael J Clague
Journal:  Life Sci Alliance       Date:  2020-07-07

3.  Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis.

Authors:  Anne-Sophie Lamort; Yveline Hamon; Cezary Czaplewski; Artur Gieldon; Seda Seren; Laurent Coquet; Fabien Lecaille; Adam Lesner; Gilles Lalmanach; Francis Gauthier; Dieter Jenne; Brice Korkmaz
Journal:  Int J Mol Sci       Date:  2019-09-25       Impact factor: 5.923

4.  Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors.

Authors:  Laura E de Vries; Mateo I Sanchez; Katarzyna Groborz; Laurie Kuppens; Marcin Poreba; Christine Lehmann; Neysa Nevins; Chrislaine Withers-Martinez; David J Hirst; Fang Yuan; Shirin Arastu-Kapur; Martin Horn; Michael Mares; Matthew Bogyo; Marcin Drag; Edgar Deu
Journal:  FEBS J       Date:  2019-06-24       Impact factor: 5.542

5.  Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening.

Authors:  Mateo I Sanchez; Laura E de Vries; Christine Lehmann; Jeong T Lee; Kenny K Ang; Christopher Wilson; Steven Chen; Michelle R Arkin; Matthew Bogyo; Edgar Deu
Journal:  PLoS One       Date:  2019-12-18       Impact factor: 3.240

Review 6.  USP30: Structure, Emerging Physiological Role, and Target Inhibition.

Authors:  Feng Wang; Yu Gao; Lihui Zhou; Junhao Chen; Zhiyan Xie; Zifan Ye; Yanfeng Wang
Journal:  Front Pharmacol       Date:  2022-03-03       Impact factor: 5.810

7.  N-Acetyldopamine dimers from Oxya chinensis sinuosa attenuates lipopolysaccharides induced inflammation and inhibits cathepsin C activity.

Authors:  Ashutosh Bahuguna; Tejinder Pal Khaket; Vivek K Bajpai; Shruti Shukla; InWha Park; MinKyun Na; Yun Suk Huh; Young-Kyu Han; Sun Chul Kang; Myunghee Kim
Journal:  Comput Struct Biotechnol J       Date:  2022-02-15       Impact factor: 7.271

8.  Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.

Authors:  Yuqing Jia; Robbert Q Kim; Raymond Kooij; Huib Ovaa; Aysegul Sapmaz; Paul P Geurink
Journal:  J Med Chem       Date:  2022-09-23       Impact factor: 8.039

Review 9.  Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

Authors:  Brice Korkmaz; Adam Lesner; Sylvain Marchand-Adam; Celia Moss; Dieter E Jenne
Journal:  J Med Chem       Date:  2020-08-07       Impact factor: 7.446
  9 in total

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