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Literature DB >> 16642961

New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy.

Abstract

Insulin resistance plays a major role in the pathogenesis of type 2 diabetes, yet despite much effort, the underlying factors that are responsible for it are poorly understood. In this review, we focus on some recent advances in our understanding of the pathogenesis of insulin resistance in humans that have been made using magnetic resonance spectroscopy.

Entities: Disease Gene Species

Mesh：

Substances：
Blood Glucose
Fatty Acids

Year: 2006 PMID： 16642961 PMCID： PMC3902166 DOI： 10.1038/oby.2006.280

Source DB: PubMed Journal: Obesity (Silver Spring) ISSN： 1930-7381 Impact factor: 5.002

47 in total

1. TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.

Authors: S P Azen; R K Peters; K Berkowitz; S Kjos; A Xiang; T A Buchanan
Journal: Control Clin Trials Date: 1998-04

2. 13C/31P NMR studies on the mechanism of insulin resistance in obesity.

Authors: K F Petersen; R Hendler; T Price; G Perseghin; D L Rothman; N Held; J M Amatruda; G I Shulman
Journal: Diabetes Date: 1998-03 Impact factor: 9.461

3. Mechanism of free fatty acid-induced insulin resistance in humans.

Authors: M Roden; T B Price; G Perseghin; K F Petersen; D L Rothman; G W Cline; G I Shulman
Journal: J Clin Invest Date: 1996-06-15 Impact factor: 14.808

4. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects.

Authors: G Perseghin; T B Price; K F Petersen; M Roden; G W Cline; K Gerow; D L Rothman; G I Shulman
Journal: N Engl J Med Date: 1996-10-31 Impact factor: 91.245

5. Pathogenesis of NIDDM. A balanced overview.

Authors: R A DeFronzo; R C Bonadonna; E Ferrannini
Journal: Diabetes Care Date: 1992-03 Impact factor: 19.112

6. Life without white fat: a transgenic mouse.

Authors: J Moitra; M M Mason; M Olive; D Krylov; O Gavrilova; B Marcus-Samuels; L Feigenbaum; E Lee; T Aoyama; M Eckhaus; M L Reitman; C Vinson
Journal: Genes Dev Date: 1998-10-15 Impact factor: 11.361

7. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.

Authors: G S Hotamisligil; P Peraldi; A Budavari; R Ellis; M F White; B M Spiegelman
Journal: Science Date: 1996-02-02 Impact factor: 47.728

8. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

Authors: M J Yin; Y Yamamoto; R B Gaynor
Journal: Nature Date: 1998-11-05 Impact factor: 49.962

9. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.

Authors: S Lillioja; D M Mott; M Spraul; R Ferraro; J E Foley; E Ravussin; W C Knowler; P H Bennett; C Bogardus
Journal: N Engl J Med Date: 1993-12-30 Impact factor: 91.245

10. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

Authors: D L Rothman; I Magnusson; G Cline; D Gerard; C R Kahn; R G Shulman; G I Shulman
Journal: Proc Natl Acad Sci U S A Date: 1995-02-14 Impact factor: 11.205

27 in total

1. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.

Authors: Dan Gao; Shanwei Nong; Xiuqing Huang; Yonggang Lu; Hongye Zhao; Yajun Lin; Yong Man; Shu Wang; Jiefu Yang; Jian Li
Journal: J Biol Chem Date: 2010-07-20 Impact factor: 5.157

10. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: report of twelve cases and discussion of mechanism of action.

Authors: Bok Y Lee; Noori Al-Waili; Dean Stubbs; Keith Wendell; Glenn Butler; Thia Al-Waili; Ali Al-Waili
Journal: Int J Med Sci Date: 2009-12-06 Impact factor: 3.738

New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy.

1. TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.

2. 13C/31P NMR studies on the mechanism of insulin resistance in obesity.

3. Mechanism of free fatty acid-induced insulin resistance in humans.

4. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects.

5. Pathogenesis of NIDDM. A balanced overview.

6. Life without white fat: a transgenic mouse.

7. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.

8. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

9. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.

10. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

1. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.

2. Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.

3. Autoregulation of free radicals via uncoupling protein control in pancreatic beta-cell mitochondria.

Review 4. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.

5. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate.

6. miR-200s contribute to interleukin-6 (IL-6)-induced insulin resistance in hepatocytes.

7. Uptake of 18F-labeled 6-fluoro-6-deoxy-D-glucose by skeletal muscle is responsive to insulin stimulation.

8. In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis.

9. Mechanisms by which diabetes increases cardiovascular disease.

10. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: report of twelve cases and discussion of mechanism of action.