Literature DB >> 20223680

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.

Roger H Unger1, Philipp E Scherer.   

Abstract

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin. Published by Elsevier Ltd.

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Year:  2010        PMID： 20223680      PMCID： PMC2880185          DOI： 10.1016/j.tem.2010.01.009

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  49 in total

Review 1.  The metabolic syndrome and the heart--a considered opinion.

Authors:  J G Leichman; V R Lavis; D Aguilar; C R Wilson; H Taegtmeyer
Journal:  Clin Res Cardiol       Date:  2006-01       Impact factor: 5.460

2.  Surgical removal of visceral fat reverses hepatic insulin resistance.

Authors:  N Barzilai; L She; B Q Liu; P Vuguin; P Cohen; J Wang; L Rossetti
Journal:  Diabetes       Date:  1999-01       Impact factor: 9.461

3.  Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy.

Authors:  Seng Khee Gan; Katherine Samaras; Campbell H Thompson; Edward W Kraegen; Andrew Carr; David A Cooper; Donald J Chisholm
Journal:  Diabetes       Date:  2002-11       Impact factor: 9.461

Review 4.  Lipotoxic diseases.

Authors:  Roger H Unger
Journal:  Annu Rev Med       Date:  2002       Impact factor: 13.739

5.  The "metabolically-obese," normal-weight individual.

Authors:  N B Ruderman; S H Schneider; P Berchtold
Journal:  Am J Clin Nutr       Date:  1981-08       Impact factor: 7.045

6.  Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

Authors:  Mayumi Ishikawa; Yuko Iwasaki; Shigeru Yatoh; Toyonori Kato; Shin Kumadaki; Noriyuki Inoue; Takashi Yamamoto; Takashi Matsuzaka; Yoshimi Nakagawa; Naoya Yahagi; Kazuto Kobayashi; Akimitsu Takahashi; Nobuhiro Yamada; Hitoshi Shimano
Journal:  J Lipid Res       Date:  2008-08-05       Impact factor: 5.922

Review 7.  The role of transcriptional regulators in central control of appetite and body weight.

Authors:  Roberto Coppari; Giorgio Ramadori; Joel K Elmquist
Journal:  Nat Clin Pract Endocrinol Metab       Date:  2009-03

8.  Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.

Authors:  May-Yun Wang; Paul Grayburn; Shuyuan Chen; Mariella Ravazzola; Lelio Orci; Roger H Unger
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-14       Impact factor: 11.205

9.  Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

Authors:  Y P Zhou; V E Grill
Journal:  J Clin Invest       Date:  1994-02       Impact factor: 14.808

Review 10.  Selective versus total insulin resistance: a pathogenic paradox.

Authors:  Michael S Brown; Joseph L Goldstein
Journal:  Cell Metab       Date:  2008-02       Impact factor: 27.287
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  162 in total

1.  Alveolar-capillary adaptation to chronic hypoxia in the fatty lung.

Authors:  C Yilmaz; P Ravikumar; D Gyawali; R Iyer; R H Unger; C C W Hsia
Journal:  Acta Physiol (Oxf)       Date:  2014-11-25       Impact factor: 6.311

Review 2.  Adipose tissue remodeling and obesity.

Authors:  Kai Sun; Christine M Kusminski; Philipp E Scherer
Journal:  J Clin Invest       Date:  2011-06-01       Impact factor: 14.808

Review 3.  The dynamic roles of intracellular lipid droplets: from archaea to mammals.

Authors:  Denis J Murphy
Journal:  Protoplasma       Date:  2011-10-15       Impact factor: 3.356

Review 4.  Vascular repair strategies in type 2 diabetes: novel insights.

Authors:  Kira Kuschnerus; Ulf Landmesser; Nicolle Kränkel
Journal:  Cardiovasc Diagn Ther       Date:  2015-10

5.  Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

Authors:  Li Liu; Chad M Trent; Xiang Fang; Ni-Huiping Son; HongFeng Jiang; William S Blaner; Yunying Hu; Yu-Xin Yin; Robert V Farese; Shunichi Homma; Andrew V Turnbull; Jan W Eriksson; Shi-Lian Hu; Henry N Ginsberg; Li-Shin Huang; Ira J Goldberg
Journal:  J Biol Chem       Date:  2014-08-25       Impact factor: 5.157

Review 6.  Lipodystrophies: adipose tissue disorders with severe metabolic implications.

Authors:  Víctor A Cortés; Marta Fernández-Galilea
Journal:  J Physiol Biochem       Date:  2015-04-02       Impact factor: 4.158

Review 7.  Insulin resistance protects the heart from fuel overload in dysregulated metabolic states.

Authors:  Heinrich Taegtmeyer; Christophe Beauloye; Romain Harmancey; Louis Hue
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-10-04       Impact factor: 4.733

Review 8.  Obesity and cancer--mechanisms underlying tumour progression and recurrence.

Authors:  Jiyoung Park; Thomas S Morley; Min Kim; Deborah J Clegg; Philipp E Scherer
Journal:  Nat Rev Endocrinol       Date:  2014-06-17       Impact factor: 43.330

Review 9.  Innate immune activation in obesity.

Authors:  Carey N Lumeng
Journal:  Mol Aspects Med       Date:  2012-10-13

10.  Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice.

Authors:  E A Fox; J E Biddinger; K R Jones; J McAdams; A Worman
Journal:  Neuroscience       Date:  2012-10-13       Impact factor: 3.590
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