PURPOSE OF REVIEW: Not all patients with mood disorder respond well to drug treatment. Emerging data suggest that genetic mechanisms could be involved. We searched the literature database and highlighted recent molecular genetic studies pertaining to drug response in mood disorders. RECENT FINDINGS: Recent pharmacogenetic studies in mood disorders have reported generally positive findings supporting the view that genotyping may improve the confidence of prospectively identifying treatment response and adverse outcomes. SUMMARY: The evidence documenting genotype-based response to drug treatment is rapidly expanding. Genes encoding target receptors and signal transduction systems may predict the efficacy of drug therapy in mood disorders. Additional predictors of treatment response in bipolar disorder may include the immediate early genes, mitochondrial genes and epigenetic mechanisms, although some of these studies are still preliminary.
PURPOSE OF REVIEW: Not all patients with mood disorder respond well to drug treatment. Emerging data suggest that genetic mechanisms could be involved. We searched the literature database and highlighted recent molecular genetic studies pertaining to drug response in mood disorders. RECENT FINDINGS: Recent pharmacogenetic studies in mood disorders have reported generally positive findings supporting the view that genotyping may improve the confidence of prospectively identifying treatment response and adverse outcomes. SUMMARY: The evidence documenting genotype-based response to drug treatment is rapidly expanding. Genes encoding target receptors and signal transduction systems may predict the efficacy of drug therapy in mood disorders. Additional predictors of treatment response in bipolar disorder may include the immediate early genes, mitochondrial genes and epigenetic mechanisms, although some of these studies are still preliminary.
Authors: A Serretti; P N Malitas; L Mandelli; C Lorenzi; C Ploia; B Alevizos; C Nikolaou; F Boufidou; G N Christodoulou; E Smeraldi Journal: Pharmacogenomics J Date: 2004 Impact factor: 3.550
Authors: Vesa Hongisto; Nina Smeds; Stephan Brecht; Thomas Herdegen; Michael J Courtney; Eleanor T Coffey Journal: Mol Cell Biol Date: 2003-09 Impact factor: 4.272
Authors: A Rousseva; C Henry; D van den Bulke; G Fournier; J-L Laplanche; M Leboyer; F Bellivier; J-M Aubry; P Baud; M Boucherie; C Buresi; F Ferrero; A Malafosse Journal: Pharmacogenomics J Date: 2003 Impact factor: 3.550