Yu Pan1, Qi Cheng2, Mo-Shui Shan3, Jin Yan4. 1. Department of Psychology and Mental Health, Second Military Medical UniversityShanghai, China; Department of Medical Psychology, General Hospital of PLABeijing, China. 2. Department of Juvenile and Children's Behavioral Medicine, 102 Hospital of PLA Changzhou, China. 3. Department of 215 Clinical, Sleeping Center, Dalian Nursing Home Dalian, China. 4. Department of Psychology and Mental Health, Second Military Medical University Shanghai, China.
Abstract
OBJECTIVE: To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population. METHODS: A case-control study was carried out, the gene types and allele distributions of NFT gene rs2242446 and rs5569 loci in 302 depression patients and 302 healthy controls were detected by Taqman SNP genotyping technology. RESULTS: The gene types and allele frequency distributions of NFT gene rs2242446 and rs5569 loci had significant differences between case group and control group (rs2242446, x(2)=26.045, P<0.05, x(2)=8.827, P<0.05, rs5569, x(2)=42.47, P<0.05, x(2)=20.9, P<0.05). The CC genotype of NET gene rs2242446 locus and rs5569 loci was a protective factor of depression compared with the CT and TT genotypes. CONCLUSION: The NET genepoly morphism of rs2242446 and rs5569 loci was a ssociated with depression in Chinese Han population, in which the CC genotype of rs2242446 and rs5569 loci was a protective factor of depression.
OBJECTIVE: To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population. METHODS: A case-control study was carried out, the gene types and allele distributions of NFT gene rs2242446 and rs5569 loci in 302 depressionpatients and 302 healthy controls were detected by Taqman SNP genotyping technology. RESULTS: The gene types and allele frequency distributions of NFT gene rs2242446 and rs5569 loci had significant differences between case group and control group (rs2242446, x(2)=26.045, P<0.05, x(2)=8.827, P<0.05, rs5569, x(2)=42.47, P<0.05, x(2)=20.9, P<0.05). The CC genotype of NET gene rs2242446 locus and rs5569 loci was a protective factor of depression compared with the CT and TT genotypes. CONCLUSION: The NET genepoly morphism of rs2242446 and rs5569 loci was a ssociated with depression in Chinese Han population, in which the CC genotype of rs2242446 and rs5569 loci was a protective factor of depression.
Authors: Peter Zill; Rolf Engel; Thomas C Baghai; Georg Juckel; Thomas Frodl; Florian Müller-Siecheneder; Peter Zwanzger; Cornelius Schüle; Christo Minov; Stefanie Behrens; Rainer Rupprecht; Ulrich Hegerl; Hans Jürgen Möller; Brigitta Bondy Journal: Neuropsychopharmacology Date: 2002-04 Impact factor: 7.853