A new method of 3-D cephalometry Part I: the anatomic Cartesian 3-D reference system.

The purpose of this study was to present a new innovative three-dimensional (3-D) cephalometric method. Part I deals with the set-up and validation of a voxel-based semi-automatic 3-D cephalometric reference system. The CT data (DICOM 3.0 files) of 20 control patients with normal skeletal relationships were used for this study. To investigate accuracy and reliability of the 3-D cephalometric reference system (Maxilimtrade mark, version 1.3.0) a total of 42 (14 horizontal, 14 vertical and 14 transversal) orthogonal measurements were performed on each patient twice by each of two investigators. The intra-observer measurement error was less then 0.88 mm, 0.76 mm and 0.84 mm for horizontal, vertical and transversal orthogonal measurements, respectively. The inter-observer measurement error was less as 0.78 mm, 0.86 mm and 1.26 mm for horizontal, vertical and transversal orthogonal measurements, respectively. Squared correlation coefficients showed a high intra-observer and inter-observer reliability. The presented 3-D cephalometric reference system proved to be accurate and reliable and can therefore be used for 3-D cephalometric hard and soft tissue analysis.