Literature DB >> 16632360

Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G.

Jonathan W Lane1, Alberto Estevez, Kyle Mortara, Ondine Callan, Jeffrey R Spencer, Robert M Williams.   

Abstract

Analogues of the tetrahydroisoquinoline family of antitumor antibiotics, 3-epi-jorumycin (3) and 3-epi-renieramycin G (4), in addition to their respective parent natural products (-)-jorumycin (1) and (-)-renieramycin G (2) were evaluated against both human colon (HCT-116) and human lung (A549) cancer cell lines. (-)-Jorumycin (1) displayed potent growth inhibition with GI50 values in the low nanomolar range (1.9-24.3 nM), while compounds 2-4 were found to be substantially less cytotoxic (GI50 0.6-14.0 microM).

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Year:  2006        PMID： 16632360      PMCID： PMC3085926          DOI： 10.1016/j.bmcl.2006.03.042

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics.

Authors:  Jack D Scott; Robert M Williams
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2.  Asymmetric total syntheses of (-)-jorumycin, (-)-renieramycin G, 3-epi-jorumycin, and 3-epi-renieramycin G.

Authors:  Jonathan W Lane; Yuyin Chen; Robert M Williams
Journal:  J Am Chem Soc       Date:  2005-09-14       Impact factor: 15.419

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4.  A solid-supported, enantioselective synthesis suitable for the rapid preparation of large numbers of diverse structural analogues of (-)-saframycin A.

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Journal:  J Am Chem Soc       Date:  2002-11-06       Impact factor: 15.419

5.  Computer simulation of the binding of saframycin A to d (GATGCATC)2.

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Authors:  G R Pettit; J C Knight; J C Collins; D L Herald; R K Pettit; M R Boyd; V G Young
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Journal:  Anticancer Drugs       Date:  2002-07       Impact factor: 2.248
  7 in total
  11 in total

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Journal:  Br J Pharmacol       Date:  2010-11       Impact factor: 8.739

2.  Substituted Tetrahydroisoquinolines as Microtubule-destabilizing Agents in Triple Negative Human Breast Cancer Cells.

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5.  2-(2-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile.

Authors:  Yanni Ma; Yifang Sun; Feng Zheng; Wenwen Sun; Le Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-20

6.  2-(4-Bromo-phen-yl)-3,4-dihydro-isoquinolin-2-ium thio-cyanate hemihydrate.

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Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30

7.  2-(4-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile.

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Review 8.  Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

Authors:  Magbubah Essack; Vladimir B Bajic; John A C Archer
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9.  Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents.

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10.  Chemistry of Renieramycins. Part 19: Semi-Syntheses of 22-O-Amino Ester and Hydroquinone 5-O-Amino Ester Derivatives of Renieramycin M and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines.

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Journal:  Mar Drugs       Date:  2020-08-10       Impact factor: 5.118
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