| Literature DB >> 15796524 |
Collin Chan1, Richard Heid, Shengping Zheng, Jinsong Guo, Bishan Zhou, Takeshi Furuuchi, Samuel J Danishefsky.
Abstract
We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a "lynchpin" Mannich cyclization to establish the pentacyclic core (cf. 19 --> 20).Entities:
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Year: 2005 PMID： 15796524 DOI： 10.1021/ja050203t
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419