AIM: To assess the role of lactase non-persistence/persistence in school-aged children and their milk-related symptoms. METHODS: The genotypes for the C/T(-13910) variant associated with lactase non-persistence/ persistence were determined using PCR-minisequencing in a group of 172 children with a mean age of 8.6 years (SE = 0.02, 93 boys) participating in a follow-up study for cow's milk allergy. The parents were asked to assess their children's milk consumption and abdominal symptoms. RESULTS: The presence of allergy to cow's milk was not associated with the C/C(-13910) genotype related with a decline of lactase enzyme activity during childhood (lactase non-persistence). The frequency of the C/C(-13910) genotype (16%) was similar to published figures for the prevalence of adult-type hypolactasia in Finland. The majority of the children (90%) in this series consumed milk but 26% of their families suspected that their children had milk-related symptoms. Forty-eight percent of the children with the C/C(-13910) genotype did not drink milk at all or consumed a low lactose containing diet prior to the genotyping (P < 0.004 when compared to the other genotypes). CONCLUSION: Analysis of the C/T(-13910) polymorphism is an easy and reliable method for excluding adult-type hypolactasia in children with milk-related symptoms. Genotyping for this variant can be used to advise diets for children with a previous history of cow's milk allergy.
AIM: To assess the role of lactase non-persistence/persistence in school-aged children and their milk-related symptoms. METHODS: The genotypes for the C/T(-13910) variant associated with lactase non-persistence/ persistence were determined using PCR-minisequencing in a group of 172 children with a mean age of 8.6 years (SE = 0.02, 93 boys) participating in a follow-up study for cow's milk allergy. The parents were asked to assess their children's milk consumption and abdominal symptoms. RESULTS: The presence of allergy to cow's milk was not associated with the C/C(-13910) genotype related with a decline of lactase enzyme activity during childhood (lactase non-persistence). The frequency of the C/C(-13910) genotype (16%) was similar to published figures for the prevalence of adult-type hypolactasia in Finland. The majority of the children (90%) in this series consumed milk but 26% of their families suspected that their children had milk-related symptoms. Forty-eight percent of the children with the C/C(-13910) genotype did not drink milk at all or consumed a low lactose containing diet prior to the genotyping (P < 0.004 when compared to the other genotypes). CONCLUSION: Analysis of the C/T(-13910) polymorphism is an easy and reliable method for excluding adult-type hypolactasia in children with milk-related symptoms. Genotyping for this variant can be used to advise diets for children with a previous history of cow's milk allergy.
Authors: K M Saarinen; K Juntunen-Backman; A L Järvenpää; P Kuitunen; L Lope; M Renlund; M Siivola; E Savilahti Journal: J Allergy Clin Immunol Date: 1999-08 Impact factor: 10.793
Authors: H Rasinperä; C Forsblom; N S Enattah; P Halonen; K Salo; M Victorzon; J-P Mecklin; H Järvinen; S Enholm; G Sellick; H Alazzouzi; R Houlston; J Robinson; P-H Groop; I Tomlinson; S Schwartz; L A Aaltonen; I Järvelä Journal: Gut Date: 2005-05 Impact factor: 23.059
Authors: S Sulkanen; T Halttunen; K Laurila; K L Kolho; I R Korponay-Szabó; A Sarnesto; E Savilahti; P Collin; M Mäki Journal: Gastroenterology Date: 1998-12 Impact factor: 22.682
Authors: Sari R Anthoni; Heli A Rasinperä; Antti J Kotamies; Hanna A Komu; Harri K Pihlajamäki; Kaija Leena Kolho; Irma E Järvelä Journal: World J Gastroenterol Date: 2007-02-28 Impact factor: 5.742