BACKGROUND AND AIMS: The role of nutrition in the pathogenesis of colorectal cancer is not fully understood. Milk products are an essential part of human nutrition in Western countries. Absorption of lactose, the main sugar of milk, is regulated by the activity of the lactase enzyme in the gut wall. The activity of lactase is genetically determined and is associated with a C/T single nucleotide polymorphism residing 13910 bp upstream of the lactase coding sequence. Here we have studied the relationship between the C/T(-13910) polymorphism and colorectal cancer in Finnish, British, and Spanish populations. PATIENTS AND METHODS: A total of 2766 subjects, including 963 Finnish, 283 British, and 163 Spanish subjects with colorectal cancer, and 773 Finnish, 363 British, and 221 Spanish control subjects, were genotyped for the C/T(-13910) variant by polymerase chain reaction minisequencing. RESULTS: The C/C(-13910) genotype, which is a robust molecular marker of low lactase activity (lactase non-persistence), was found to significantly associate with the risk of colorectal cancer (p = 0.015) in the Finnish subjects, with an odds ratio of 1.40 (95% confidence interval 1.07-1.85). No association was found with site, histology, or stage of the tumour. No significant risk was detected in the British or Spanish populations. CONCLUSION: Low lactase enzyme activity, defined by genotyping of the C/T(-13910) variant, may increase the risk of colorectal cancer. Further studies are warranted to investigate the role of milk and other dairy products in the pathogenesis of colon cancer in different populations.
BACKGROUND AND AIMS: The role of nutrition in the pathogenesis of colorectal cancer is not fully understood. Milk products are an essential part of human nutrition in Western countries. Absorption of lactose, the main sugar of milk, is regulated by the activity of the lactase enzyme in the gut wall. The activity of lactase is genetically determined and is associated with a C/T single nucleotide polymorphism residing 13910 bp upstream of the lactase coding sequence. Here we have studied the relationship between the C/T(-13910) polymorphism and colorectal cancer in Finnish, British, and Spanish populations. PATIENTS AND METHODS: A total of 2766 subjects, including 963 Finnish, 283 British, and 163 Spanish subjects with colorectal cancer, and 773 Finnish, 363 British, and 221 Spanish control subjects, were genotyped for the C/T(-13910) variant by polymerase chain reaction minisequencing. RESULTS: The C/C(-13910) genotype, which is a robust molecular marker of low lactase activity (lactase non-persistence), was found to significantly associate with the risk of colorectal cancer (p = 0.015) in the Finnish subjects, with an odds ratio of 1.40 (95% confidence interval 1.07-1.85). No association was found with site, histology, or stage of the tumour. No significant risk was detected in the British or Spanish populations. CONCLUSION: Low lactase enzyme activity, defined by genotyping of the C/T(-13910) variant, may increase the risk of colorectal cancer. Further studies are warranted to investigate the role of milk and other dairy products in the pathogenesis of colon cancer in different populations.
Authors: P Pietinen; N Malila; M Virtanen; T J Hartman; J A Tangrea; D Albanes; J Virtamo Journal: Cancer Causes Control Date: 1999-10 Impact factor: 2.506
Authors: Nabil Sabri Enattah; Timo Sahi; Erkki Savilahti; Joseph D Terwilliger; Leena Peltonen; Irma Järvelä Journal: Nat Genet Date: 2002-01-14 Impact factor: 38.330
Authors: J Ma; E Giovannucci; M Pollak; J M Chan; J M Gaziano; W Willett; M J Stampfer Journal: J Natl Cancer Inst Date: 2001-09-05 Impact factor: 13.506
Authors: B M Obermayer-Pietsch; M Gugatschka; S Reitter; W Plank; A Strele; D Walter; C Bonelli; W Goessler; H Dobnig; C Högenauer; W Renner; A Fahrleitner-Pammer Journal: Osteoporos Int Date: 2006-11-14 Impact factor: 4.507
Authors: Heli Rasinpera; Kristiina Saarinen; Anna Pelkonen; Irma Jarvela; Erkki Savilahti; Kaija-Leena Kolho Journal: World J Gastroenterol Date: 2006-04-14 Impact factor: 5.742
Authors: George Davey Smith; Debbie A Lawlor; Nic J Timpson; Jamil Baban; Matt Kiessling; Ian N M Day; Shah Ebrahim Journal: Eur J Hum Genet Date: 2008-09-17 Impact factor: 4.246
Authors: Jeroen R Huyghe; Tabitha A Harrison; Stephanie A Bien; Heather Hampel; Jane C Figueiredo; Stephanie L Schmit; David V Conti; Sai Chen; Conghui Qu; Yi Lin; Richard Barfield; John A Baron; Amanda J Cross; Brenda Diergaarde; David Duggan; Sophia Harlid; Liher Imaz; Hyun Min Kang; David M Levine; Vittorio Perduca; Aurora Perez-Cornago; Lori C Sakoda; Fredrick R Schumacher; Martha L Slattery; Amanda E Toland; Fränzel J B van Duijnhoven; Bethany Van Guelpen; Antonio Agudo; Demetrius Albanes; M Henar Alonso; Kristin Anderson; Coral Arnau-Collell; Volker Arndt; Barbara L Banbury; Michael C Bassik; Sonja I Berndt; Stéphane Bézieau; D Timothy Bishop; Juergen Boehm; Heiner Boeing; Marie-Christine Boutron-Ruault; Hermann Brenner; Stefanie Brezina; Stephan Buch; Daniel D Buchanan; Andrea Burnett-Hartman; Bette J Caan; Peter T Campbell; Prudence R Carr; Antoni Castells; Sergi Castellví-Bel; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Keith R Curtis; Albert de la Chapelle; Douglas F Easton; Dallas R English; Edith J M Feskens; Manish Gala; Steven J Gallinger; W James Gauderman; Graham G Giles; Phyllis J Goodman; William M Grady; John S Grove; Andrea Gsur; Marc J Gunter; Robert W Haile; Jochen Hampe; Michael Hoffmeister; John L Hopper; Wan-Ling Hsu; Wen-Yi Huang; Thomas J Hudson; Mazda Jenab; Mark A Jenkins; Amit D Joshi; Temitope O Keku; Charles Kooperberg; Tilman Kühn; Sébastien Küry; Loic Le Marchand; Flavio Lejbkowicz; Christopher I Li; Li Li; Wolfgang Lieb; Annika Lindblom; Noralane M Lindor; Satu Männistö; Sanford D Markowitz; Roger L Milne; Lorena Moreno; Neil Murphy; Rami Nassir; Kenneth Offit; Shuji Ogino; Salvatore Panico; Patrick S Parfrey; Rachel Pearlman; Paul D P Pharoah; Amanda I Phipps; Elizabeth A Platz; John D Potter; Ross L Prentice; Lihong Qi; Leon Raskin; Gad Rennert; Hedy S Rennert; Elio Riboli; Clemens Schafmayer; Robert E Schoen; Daniela Seminara; Mingyang Song; Yu-Ru Su; Catherine M Tangen; Stephen N Thibodeau; Duncan C Thomas; Antonia Trichopoulou; Cornelia M Ulrich; Kala Visvanathan; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Korbinian Weigl; Stephanie J Weinstein; Emily White; Alicja Wolk; Michael O Woods; Anna H Wu; Goncalo R Abecasis; Deborah A Nickerson; Peter C Scacheri; Anshul Kundaje; Graham Casey; Stephen B Gruber; Li Hsu; Victor Moreno; Richard B Hayes; Polly A Newcomb; Ulrike Peters Journal: Gut Date: 2021-02-25 Impact factor: 31.793
Authors: Krisztián Bácsi; Erika Hitre; János P Kósa; Henrik Horváth; Aron Lazáry; Péter L Lakatos; Bernadett Balla; Barna Budai; Péter Lakatos; Gábor Speer Journal: BMC Cancer Date: 2008-11-03 Impact factor: 4.430