BACKGROUND: This study explores the effect of age at the time of parental cancer diagnosis or death on psychological distress and cancer risk perception in individuals undergoing genetic testing for a specific cancer susceptibility. PATIENTS AND METHODS: Cancer-related distress, worry and risk perception were assessed in 271 applicants for genetic testing of an identified mutation in BRCA1/2 (BReast CAncer) or a HNPCC (Hereditary Nonpolyposis Colorectal Cancer) related gene before, one week after, and six months after genetic test disclosure. The course of distress and risk perception were compared between individuals having witnessed parental cancer or loss due to cancer in childhood, adolescence, adulthood and having unaffected parents. RESULTS: Individuals with parental cancer in childhood (under age 13) reported the highest level of cancer related distress, worry and risk perception. Women having their mother affected by breast cancer in puberty (aged 10-13 years) perceived higher breast cancer risks than women with an affected mother in adulthood or without an affected mother. Individuals with an affected parent perceived cancer risks as higher than individuals without an affected parent, but were not more distressed. CONCLUSIONS: Experience of parental cancer in childhood is a risk factor for psychological distress during the genetic testing process.
BACKGROUND: This study explores the effect of age at the time of parental cancer diagnosis or death on psychological distress and cancer risk perception in individuals undergoing genetic testing for a specific cancer susceptibility. PATIENTS AND METHODS: Cancer-related distress, worry and risk perception were assessed in 271 applicants for genetic testing of an identified mutation in BRCA1/2 (BReast CAncer) or a HNPCC (Hereditary Nonpolyposis Colorectal Cancer) related gene before, one week after, and six months after genetic test disclosure. The course of distress and risk perception were compared between individuals having witnessed parental cancer or loss due to cancer in childhood, adolescence, adulthood and having unaffected parents. RESULTS: Individuals with parental cancer in childhood (under age 13) reported the highest level of cancer related distress, worry and risk perception. Women having their mother affected by breast cancer in puberty (aged 10-13 years) perceived higher breast cancer risks than women with an affected mother in adulthood or without an affected mother. Individuals with an affected parent perceived cancer risks as higher than individuals without an affected parent, but were not more distressed. CONCLUSIONS: Experience of parental cancer in childhood is a risk factor for psychological distress during the genetic testing process.
Authors: Kenneth P Tercyak; Darren Mays; Tiffani A DeMarco; Beth N Peshkin; Heiddis B Valdimarsdottir; Katherine A Schneider; Judy E Garber; Andrea Farkas Patenaude Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-07 Impact factor: 4.254
Authors: M J Esplen; J Wong; M Aronson; K Butler; H Rothenmund; K Semotiuk; L Madlensky; C Way; E Dicks; J Green; S Gallinger Journal: Clin Genet Date: 2014-10-28 Impact factor: 4.438
Authors: Beth N Peshkin; Tiffani A DeMarco; Judy E Garber; Heiddis B Valdimarsdottir; Andrea F Patenaude; Katherine A Schneider; Marc D Schwartz; Kenneth P Tercyak Journal: J Pediatr Psychol Date: 2008-04-01
Authors: Eveline M A Bleiker; Mary Jane Esplen; Bettina Meiser; Helle Vendel Petersen; Andrea Farkas Patenaude Journal: Fam Cancer Date: 2013-06 Impact factor: 2.375
Authors: Angela R Bradbury; Linda Patrick-Miller; Kimberly Pawlowski; Comfort N Ibe; Shelly A Cummings; Fay Hlubocky; Olufunmilayo I Olopade; Christopher K Daugherty Journal: Psychooncology Date: 2009-02 Impact factor: 3.894