Literature DB >> 16596415

Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.

Alessandra Jorqueira1, Robson M Gouvêa, Vitor F Ferreira, Milton N da Silva, Maria C B V de Souza, Aline A Zuma, Danielle F B Cavalcanti, Humberto P Araújo, Dilvani O Santos, Saulo C Bourguignon.   

Abstract

The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-lapachone showed an approximately the same trypanocidal activity of beta-lapachone. In addition, all the oxyranes showed less cytotoxicity than the corresponding naphthoquinones.

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Year:  2006        PMID： 16596415     DOI： 10.1007/s00436-006-0153-8

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.383


  32 in total

1.  Molluscicidal and trypanocidal activities of lapachol derivatives.

Authors:  A F Santos; P A Ferraz; F C de Abreu; E Chiari; M O Goulart; A E Sant'Ana
Journal:  Planta Med       Date:  2001-02       Impact factor: 3.352

2.  Evaluation of different staining procedures for the quantification of fibroblasts cultured in 96-well plates.

Authors:  M A Scragg; L R Ferreira
Journal:  Anal Biochem       Date:  1991-10       Impact factor: 3.365

Review 3.  Quinone chemistry and toxicity.

Authors:  T J Monks; R P Hanzlik; G M Cohen; D Ross; D G Graham
Journal:  Toxicol Appl Pharmacol       Date:  1992-01       Impact factor: 4.219

Review 4.  Superoxide: a two-edged sword.

Authors:  B M Babior
Journal:  Braz J Med Biol Res       Date:  1997-02       Impact factor: 2.590

5.  Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots.

Authors:  S Gafner; J L Wolfender; M Nianga; H Stoeckli-Evans; K Hostettmann
Journal:  Phytochemistry       Date:  1996-07       Impact factor: 4.072

Review 6.  Recent studies on natural products as anticancer agents.

Authors:  Angel G Ravelo; Ana Estévez-Braun; Haydee Chávez-Orellana; Elisa Pérez-Sacau; Dulce Mesa-Siverio
Journal:  Curr Top Med Chem       Date:  2004       Impact factor: 3.295

7.  Quantitative structure-activity relationship in aziridinyl-1,4-naphthoquinone antimalarials: study of theoretical correlations by the PM3 method.

Authors:  Elizabeth V M dos Santos; José W de M Carneiro; Vitor F Ferreira
Journal:  Bioorg Med Chem       Date:  2004-01-02       Impact factor: 3.641

8.  Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of beta-lapachone.

Authors:  P H Di Chenna; V Benedetti-Doctorovich; R F Baggio; M T Garland; G Burton
Journal:  J Med Chem       Date:  2001-07-19       Impact factor: 8.039

9.  Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone.

Authors:  Kelly C G De Moura; Kelly Salomão; Rubem F S Menna-Barreto; Flávio S Emery; Maria do Carmo F R Pinto; Antônio V Pinto; Solange L de Castro
Journal:  Eur J Med Chem       Date:  2004-07       Impact factor: 7.088

10.  beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.

Authors:  C J Li; L Averboukh; A B Pardee
Journal:  J Biol Chem       Date:  1993-10-25       Impact factor: 5.486
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  4 in total

1.  Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite.

Authors:  Franklin Souza-Silva; Saulo Cabral Bourguignon; Bernardo Acácio Santini Pereira; Luzia Monteiro de Castro Côrtes; Luiz Filipe Gonçalves de Oliveira; Andrea Henriques-Pons; Lea Cysne Finkelstein; Vitor Francisco Ferreira; Paula Fernandes Carneiro; Rosa Teixeira de Pinho; Ernesto Raul Caffarena; Carlos Roberto Alves
Journal:  Antimicrob Agents Chemother       Date:  2015-01-12       Impact factor: 5.191

2.  The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis.

Authors:  Luiz Filipe Gonçalves-Oliveira; Franklin Souza-Silva; Luzia Monteiro de Castro Côrtes; Laura Barral Veloso; Bernardo Acácio Santini Pereira; Lea Cysne-Finkelstein; Guilherme Curty Lechuga; Saulo Cabral Bourguignon; Fernando Almeida-Souza; Kátia da Silva Calabrese; Vitor Francisco Ferreira; Carlos Roberto Alves
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2019-08-12       Impact factor: 4.077

3.  In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Authors:  Juliana Figueiredo Peixoto; Adriane da Silva Oliveira; Patrícia Queiroz Monteiro; Luiz Filipe Gonçalves-Oliveira; Valter Viana Andrade-Neto; Vitor Francisco Ferreira; Franklin Souza-Silva; Carlos Roberto Alves
Journal:  Molecules       Date:  2021-06-10       Impact factor: 4.411

4.  Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication.

Authors:  Emmerson C B da Costa; Raquel Amorim; Fernando C da Silva; David R Rocha; Michelle P Papa; Luciana B de Arruda; Ronaldo Mohana-Borges; Vitor F Ferreira; Amilcar Tanuri; Luciana J da Costa; Sabrina B Ferreira
Journal:  PLoS One       Date:  2013-12-20       Impact factor: 3.240
  4 in total

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