Literature DB >> 11270734

Molluscicidal and trypanocidal activities of lapachol derivatives.

A F Santos, P A Ferraz, F C de Abreu, E Chiari, M O Goulart, A E Sant'Ana.   

Abstract

The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC50 values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T. cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7% of the parasites at the concentration of 42 microg/mL.

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Year:  2001        PMID： 11270734     DOI： 10.1055/s-2001-10877

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  2 in total

1.  3-(2,4-Dibromo-anilino)-2,2-dimethyl-2,3-dihydro-naphtho[1,2-b]furan-4,5-dione: a new substituted aryl-amino nor-β-lapachone derivative.

Authors:  Eufrânio N da Silva; Carlos A De Simone; Marília O F Goulart; Carlos K Z Andrade; Raphael S F Silva; Antonio V Pinto
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-13

2.  Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.

Authors:  Alessandra Jorqueira; Robson M Gouvêa; Vitor F Ferreira; Milton N da Silva; Maria C B V de Souza; Aline A Zuma; Danielle F B Cavalcanti; Humberto P Araújo; Dilvani O Santos; Saulo C Bourguignon
Journal:  Parasitol Res       Date:  2006-04-05       Impact factor: 2.383
  2 in total

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