Literature DB >> 16586379

The Antimicrobial Treatment Strategies (MIKSTRA) program: a 5-year follow-up of infection-specific antibiotic use in primary health care and the effect of implementation of treatment guidelines.

Ulla-Maija Rautakorpi1, Solja Huikko, Pekka Honkanen, Timo Klaukka, Marjukka Makela, Erkki Palva, Risto Roine, Hannu Sarkkinen, Helena Varonen, Pentti Huovinen.   

Abstract

BACKGROUND: A national 5-year follow-up study of infection-specific antibiotic use in primary care was conducted to see if prescribing practices change after implementing new treatment guidelines.
METHODS: The data were collected during 1 week of November each year from 1998 to 2002 from 30 health care centers that covered a total population of 819,777 persons and in 2002 from 20 control health care centers that covered a population of 545,098 persons. National guidelines for 6 major infections (otitis media, sinusitis, throat infection, acute bronchitis, urinary tract infection, and bacterial skin infection) were published in 1999-2000. Multifaceted interventions were performed by local trainers teaching his or her coworkers, supported by feedback and patient and public information.
RESULTS: The 6 infections targeted for intervention, together with unspecified upper respiratory tract infection constituted 80%-85% of all infections. The proportion of patients who received prescriptions for antibiotics did not change significantly. However, use of first-line antibiotics increased for all infections, and the change was significant for sinusitis (P<.001), acute bronchitis (P=.015), and urinary tract infections (P=.009). Also, the percentage of antibiotic treatments prescribed for the recommended duration increased significantly. Correct prescribing for respiratory tract infections improved by 6.4 percentage units (P<.001). However, there was no statistically significant difference in performance between study and control health care centers at follow-up.
CONCLUSIONS: Moderate qualitative improvements in antibiotic use were observed after multifaceted intervention, but prescribing for unjustified indications, mainly acute bronchitis, did not decrease. Obtained infection-specific information on management of patients with infections in primary health care is an important basis for planning targeted interventions in the future.

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Year:  2006        PMID: 16586379     DOI: 10.1086/503036

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  10 in total

1.  Long-term effects of an educational seminar on antibiotic prescribing by GPs: a randomised controlled trial.

Authors:  Philippe Le Corvoisier; Vincent Renard; Françoise Roudot-Thoraval; Thierry Cazalens; Kalaivani Veerabudun; Florence Canoui-Poitrine; Olivier Montagne; Claude Attali
Journal:  Br J Gen Pract       Date:  2013-07       Impact factor: 5.386

2.  The antibiotic revolution should be more focused.

Authors:  Theo J M Verheij
Journal:  Br J Gen Pract       Date:  2009-10       Impact factor: 5.386

Review 3.  Effectiveness of physician-targeted interventions to improve antibiotic use for respiratory tract infections.

Authors:  Alike W van der Velden; Eefje J Pijpers; Marijke M Kuyvenhoven; Sarah K G Tonkin-Crine; Paul Little; Theo J M Verheij
Journal:  Br J Gen Pract       Date:  2012-12       Impact factor: 5.386

4.  Screening of urine samples by flow cytometry reduces the need for culture.

Authors:  Santra Jolkkonen; Eeva-Liisa Paattiniemi; Pauliina Kärpänoja; Hannu Sarkkinen
Journal:  J Clin Microbiol       Date:  2010-06-30       Impact factor: 5.948

5.  Influence of patient payment on antibiotic prescribing in Irish general practice: a cohort study.

Authors:  Marion Murphy; Stephen Byrne; Colin P Bradley
Journal:  Br J Gen Pract       Date:  2011-09       Impact factor: 5.386

Review 6.  Streptococcus pyogenes and re-emergence of scarlet fever as a public health problem.

Authors:  Samson Sy Wong; Kwok-Yung Yuen
Journal:  Emerg Microbes Infect       Date:  2012-07-11       Impact factor: 7.163

7.  Reduction of antibiotic prescriptions for acute respiratory tract infections in primary care: a systematic review.

Authors:  Anna Köchling; Christin Löffler; Stefan Reinsch; Anne Hornung; Femke Böhmer; Attila Altiner; Jean-François Chenot
Journal:  Implement Sci       Date:  2018-03-20       Impact factor: 7.327

8.  The state of play in the battle against antimicrobial resistance: a general practitioner perspective.

Authors:  Douglas M Fleming
Journal:  J Antimicrob Chemother       Date:  2007-08       Impact factor: 5.790

9.  Nasal saline irrigation: prescribing habits and attitudes of physicians and pharmacists.

Authors:  Jesse Tapiala; Antti Hyvärinen; Sanna Toppila-Salmi; Eero Suihko; Elina Penttilä
Journal:  Scand J Prim Health Care       Date:  2021-02-11       Impact factor: 2.581

10.  Immune Defense in Upper Airways: A Single-Cell Study of Pathogen-Specific Plasmablasts and Their Migratory Potentials in Acute Sinusitis and Tonsillitis.

Authors:  Nina V Palkola; Karin Blomgren; Sari H Pakkanen; Ritvaleena Puohiniemi; Jussi M Kantele; Anu Kantele
Journal:  PLoS One       Date:  2016-04-29       Impact factor: 3.240

  10 in total

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