Literature DB >> 16563751

Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia.

Shui-Chun Mao1, Yue-Wei Guo, Xu Shen.   

Abstract

Caulerpal A (2) and B (3), two novel sesquiterpenes possessing an uncommon aromatic valerenane-type carbon skeleton, along with one known metabolite, caulerpin (4), have been isolated from the Chinese green alga Caulerpa taxifolia (Vahl) C. Agardh. Their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analysis. Compounds 2-4 were evaluated for their inhibitory activity against hPTP1B and the result showed that only compound 4 had a strong PTP1B inhibitory activity with an IC50 value of 3.77 microM.

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Year:  2006        PMID： 16563751     DOI： 10.1016/j.bmcl.2006.02.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

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